The circadian system: a regulatory feedback network of periphery and brain

FN Buijs, L León-Mercado, M Guzmán-Ruiz… - …, 2016 - journals.physiology.org
Circadian rhythms are generated by the autonomous circadian clock, the suprachiasmatic
nucleus (SCN), and clock genes that are present in all tissues. The SCN times these …

[HTML][HTML] Timing to perfection: the biology of central and peripheral circadian clocks

U Albrecht - Neuron, 2012 - cell.com
The mammalian circadian system, which is comprised of multiple cellular clocks located in
the organs and tissues, orchestrates their regulation in a hierarchical manner throughout the …

Interaction of central and peripheral clocks in physiological regulation

JL Barclay, AH Tsang, H Oster - Progress in brain research, 2012 - Elsevier
In mammals, circadian rhythms of physiology and behavior are regulated by a complex
network of cellular molecular oscillators distributed throughout the brain and peripheral …

Circadian synchrony: sleep, nutrition, and physical activity

KL Healy, AR Morris, AC Liu - Frontiers in network physiology, 2021 - frontiersin.org
The circadian clock in mammals regulates the sleep/wake cycle and many associated
behavioral and physiological processes. The cellular clock mechanism involves a …

Two decades of circadian time

MH Hastings, ES Maywood… - Journal of …, 2008 - Wiley Online Library
Circadian rhythms coordinate our physiology at a fundamental level. Over the last 20 years,
we have witnessed a paradigm shift in our perception of what the clocks driving such …

Inputs and outputs of the mammalian circadian clock

AN Starnes, JR Jones - Biology, 2023 - mdpi.com
Simple Summary In mammals, circadian rhythms in nearly all behaviors and physiological
processes are controlled by the suprachiasmatic nucleus, a collection of neurons in the …

Circadian timing in health and disease

ES Maywood, J O'Neill, GKY Wong, AB Reddy… - Progress in brain …, 2006 - Elsevier
Metabolic status varies predictably on a daily and seasonal basis in order to adapt to the
cyclical environment. The hypothalamic circadian pacemaker of the suprachiasmatic nuclei …

Brain clocks: from the suprachiasmatic nuclei to a cerebral network

J Mendoza, E Challet - The Neuroscientist, 2009 - journals.sagepub.com
Circadian timing affects almost all life's processes. It not only dictates when we sleep, but
also keeps every cell and tissue working under a tight temporal regimen. The daily …

Mechanisms of communication in the mammalian circadian timing system

M Astiz, I Heyde, H Oster - International journal of molecular sciences, 2019 - mdpi.com
24-h rhythms in physiology and behaviour are organized by a body-wide network of
endogenous circadian clocks. In mammals, a central pacemaker in the hypothalamic …

Clock genes and metabolic disease

B Marcheva, KM Ramsey… - Journal of applied …, 2009 - journals.physiology.org
The circadian system is a key integrator of behavior and metabolism that synchronizes
physiological processes with the rotation of the Earth on its axis. In mammals, the clock is …