[HTML][HTML] Systems biology in inflammatory bowel diseases: on the way to precision medicine

N Dovrolis, E Filidou, G Kolios - Annals of Gastroenterology, 2019 - ncbi.nlm.nih.gov
Inflammatory bowel diseases (IBD) are chronic and recurrent inflammatory disorders of the
gastrointestinal tract. The elucidation of their etiopathology requires complex and multiple …

Inflammatory bowel disease meets systems biology: a multi-omics challenge and frontier

O Palmieri, T Mazza, S Castellana, A Panza… - OMICS: A Journal of …, 2016 - liebertpub.com
The inflammatory bowel disease (IBD) is a systemic disease that is characterized by the
inflammation of the gastrointestinal tract. It includes ulcerative colitis and the Crohn's …

IBD systems biology is here to stay

C Fiocchi, D Iliopoulos - Inflammatory bowel diseases, 2021 - academic.oup.com
Background Systems biology is a rapidly advancing field of science that allows us to look
into disease mechanisms, patient diagnosis and stratification, and drug development in a …

[HTML][HTML] Network biology approaches to achieve precision medicine in inflammatory bowel disease

JP Thomas, D Modos, T Korcsmaros… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic immune-mediated condition arising due to
complex interactions between multiple genetic and environmental factors. Despite recent …

Network analysis of inflammatory bowel disease research: towards the interactome

ME Fernandez, FN Nazar, LB Moine… - Journal of Crohn's …, 2022 - academic.oup.com
Abstract Background and Aims Modern views accept that inflammatory bowel diseases [IBD]
emerge from complex interactions among the multiple components of a biological network …

An integrative analysis of gene expression and molecular interaction data to identify dys-regulated sub-networks in inflammatory bowel disease

D Muraro, A Simmons - BMC bioinformatics, 2016 - Springer
Background Inflammatory bowel disease (IBD) consists of two main disease-subtypes,
Crohn's disease (CD) and ulcerative colitis (UC); these subtypes share overlapping genetic …

Systems biology in inflammatory bowel diseases: ready for prime time

C Polytarchou, G Koukos… - Current opinion in …, 2014 - journals.lww.com
A systems biology approach could potentially identify the central regulators (hubs) in the IBD
interactome and improve our understanding of the molecular mechanisms involved in IBD …

Systems biology approaches for inflammatory bowel disease: emphasis on gut microbial metabolism

S Moco, M Candela, E Chuang, C Draper… - Inflammatory bowel …, 2014 - academic.oup.com
Although the prevalence of main idiopathic forms of inflammatory bowel disease (IBD) has
risen considerably over the last decades, their clinical features do not allow accurate …

Dysbiosis in inflammatory bowel disease: pathogenic role and potential therapeutic targets

PT Santana, SLB Rosas, BE Ribeiro, Y Marinho… - International journal of …, 2022 - mdpi.com
Microbe–host communication is essential to maintain vital functions of a healthy host, and its
disruption has been associated with several diseases, including Crohn's disease and …

Systems biology approach highlights mechanistic differences between Crohn's disease and ulcerative colitis

PA Ruiz Castro, H Yepiskoposyan, S Gubian… - Scientific Reports, 2021 - nature.com
The molecular mechanisms of IBD have been the subject of intensive exploration. We,
therefore, assembled the available information into a suite of causal biological network …