The concept of the CNS as an immune-privileged organ has led to a common
misunderstanding that it is not an active immunological organ, guarded from its …

The brain is in many ways an immunologically and pharmacologically privileged site. The
blood–brain barrier (BBB) of the cerebrovascular endothelium and its participation in the …

The immune system's role is much more than merely recognizing self vs. non-self and
involves maintaining homeostasis and integrity of the organism starting from early …

The blood-brain barrier (BBB) provides both anatomical and physiological protection for the
central nervous system (CNS), strictly regulating the entry of many substances and blood …

Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …

In autoimmune neurologic disorders, the blood–brain barrier (BBB) plays a central role in
immunopathogenesis, since this vascular interface is an entry path for cells and effector …

Recent advances have directed our knowledge of the immune system from a narrative of
“self” versus “nonself” to one in which immune function is critical for homeostasis of organs …

Fighting pathogens and maintaining tissue homeostasis are prerequisites for survival. Both
of these functions are upheld by the immune system, though the latter is often overlooked in …

Central nervous system (CNS) barriers predominantly mediate the immune-privileged status
of the brain, and are also important regulators of neuroimmune communication. It is …

The blood-brain barrier (BBB) is not simply a physical barrier but a regulatory interface
between the central nervous system (CNS) and immune system. The BBB both affects and is …