The induced expression of multiple drug resistance (MDR)-associated genes as a direct
response of tumor cells to antineoplastic drugs could be an important factor influencing the …

Three high-level multidrug-resistant sublines of the human T-lymphoblastoid cell line CCRF-
CEM were selected independently with either actinomycin D, vincristine or adriamycin. They …

Amplification and increased expression of the mdr 1 gene associated with multidrug
resistance in human tumors were found in multidrug-resistant sublines of human …

The multidrug resistance gene mdr1, encoding P‐glycoprotein (P‐gp), can be expressed at
high levels in tumour cells derived from normal tissues with constitutive high expression of …

Resistance to multiple chemotherapeutic agents has been related to the production of P-
glycoprotein, a trans-membrane drug efflux pump that is encoded by the multidrug …

MDR gene expression in murine leukemia L 1210 cells was investigated during treatment in
vivo with 0.5 mg doxorubicin/kg body weight (BW). Drug resistance (measured by an in vitro …

The expression of P-glycoprotein (Pgp) is often increased in acute myeloid leukemia (AML).
However, little is known of the regulation of Pgp expression by cytotoxics in AML. We …

The phenomenon of multidrug resistance (MDR) is frequently encountered in clinical
situations, and could contribute to the failure of chemotherapy in acute leukemia. Preliminary …

We determined the expression levels of the mdr1 and mdr3 multidrug-resistance genes
(also known as PGY1 and PGY3, respectively) in peripheral blood cells from 69 adult …

Multidrug resistance (MDR) in cultured human cells is caused by the overexpression of the
MDR‐1 gene. This gene codes for P‐glycoprotein, a proposed ATP‐dependent drug efflux …