The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile
M Ferracin, R Gafà, E Miotto… - The Journal of …, 2008 - Wiley Online Library
The CpG island methylator phenotype (CIMP) in colorectal tumours can be recognized by an
increased frequency of aberrant methylation in a specific set of genomic loci. Because of the …
increased frequency of aberrant methylation in a specific set of genomic loci. Because of the …
CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies
S Ogino, M Cantor, T Kawasaki, M Brahmandam… - Gut, 2006 - gut.bmj.com
Background: The concept of CpG island methylator phenotype (CIMP) is not universally
accepted. Even if specific clinicopathological features have been associated with CIMP …
accepted. Even if specific clinicopathological features have been associated with CIMP …
[HTML][HTML] Subsets of microsatellite-unstable colorectal cancers exhibit discordance between the CpG island methylator phenotype and MLH1 methylation status
JH Kim, YY Rhee, JM Bae, HJ Kwon, NY Cho, MJ Kim… - Modern Pathology, 2013 - Elsevier
Although the presence of MLH1 methylation in microsatellite-unstable colorectal cancer
generally indicates involvement of the CpG island methylator phenotype (CIMP) in the …
generally indicates involvement of the CpG island methylator phenotype (CIMP) in the …
The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer
A Goel, T Nagasaka, CN Arnold, T Inoue, C Hamilton… - Gastroenterology, 2007 - Elsevier
Background & Aims: The CpG island methylator phenotype (CIMP) is one of the
mechanisms involved in colorectal carcinogenesis (CRC). Although CIMP is probably the …
mechanisms involved in colorectal carcinogenesis (CRC). Although CIMP is probably the …
Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer
WS Samowitz, H Albertsen, J Herrick, TR Levin… - Gastroenterology, 2005 - Elsevier
Background & Aims: The concept of a CpG island methylator phenotype (CIMP), especially
in microsatellite stable colon cancer, is not accepted universally. We therefore evaluated a …
in microsatellite stable colon cancer, is not accepted universally. We therefore evaluated a …
Clinicopathological and molecular profiles of sporadic microsatellite unstable colorectal cancer with or without the CpG island methylator phenotype (CIMP)
SC Chang, AFY Li, PC Lin, CC Lin, HH Lin, SC Huang… - Cancers, 2020 - mdpi.com
Simple Summary The 5'-C-phosphate-G-3'island methylator phenotype (CIMP) is a
phenotype of colorectal cancer associated with microsatellite instability (MSI). The aim of the …
phenotype of colorectal cancer associated with microsatellite instability (MSI). The aim of the …
The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status
AM Dahlin, R Palmqvist, ML Henriksson… - Clinical cancer …, 2010 - AACR
Purpose: The aim of this study was to relate the CpG island methylator phenotype (CIMP;
characterized by extensive promoter hypermethylation) to cancer-specific survival in …
characterized by extensive promoter hypermethylation) to cancer-specific survival in …
CpG island methylator phenotypes in aging and cancer
M Toyota, JPJ Issa - Seminars in cancer biology, 1999 - Elsevier
CpG islands are short stretches of CpG rich regions that are frequently associated with the
promoter region of genes. Aberrant methylation of CpG islands is one mechanism of …
promoter region of genes. Aberrant methylation of CpG islands is one mechanism of …
18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP …
S Ogino, T Kawasaki, GJ Kirkner, M Ohnishi, CS Fuchs - BMC cancer, 2007 - Springer
Abstract Background: The CpG island methylator phenotype (CIMP) with widespread
promoter methylation is a distinct epigenetic phenotype in colorectal cancer, associated with …
promoter methylation is a distinct epigenetic phenotype in colorectal cancer, associated with …
LINE‐1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
S Ogino, T Kawasaki, K Nosho… - … journal of cancer, 2008 - Wiley Online Library
The CpG island methylator phenotype (CIMP) with widespread promoter CpG island
methylation is a phenotype in colorectal cancer, associated with microsatellite instability …
methylation is a phenotype in colorectal cancer, associated with microsatellite instability …