Adenosine receptor agonists are usually variations of the natural ligand, adenosine. The
ribose moiety in the ligand has previously been shown to be of great importance for the …

The A 2a adenosine receptor is a member of the G-protein coupled receptor family, and its
activation stimulates cyclic AMP production. To determine the residues which are involved in …

New A3 adenosine receptor antagonists were synthesized and tested at human adenosine
receptor subtypes. An advanced synthetic strategy permitted us to obtain a large amount of …

Adenosine produces a wide variety of physiological effects through the activation of cell
surface adenosine receptors (ARs). ARs are members of the G-protein-coupled receptor …

Four subtypes of adenosine receptors have recently been cloned from thyroid, brain and
testis. In this review we have summarised properties of these purinergic receptors. The …

Adenosine receptors (ARs) are a four-member subfamily of G protein-coupled receptors and
are major targets of caffeine and theophylline. There are four subtypes of ARs, designated …

The bovine brain A1 adenosine receptor (A1AR) is distinct from other A1ARs in that it
displays the unique agonist potency series of N6-R-phenylisopropyladenosine (R-PIA) …

Abstract The A 1, A 2A, A 2B and A 3 G-protein-coupled cell surface adenosine receptors
(ARs) are found to be upregulated in various tumor cells. Activation of the receptors by …

Antagonism of the human A2A receptor has been implicated as a point of therapeutic
intervention in the alleviation of the symptoms associated with Parkinson's disease. This is …

The amino acid sequence of the canine adenosine A 1 receptor and the atomic coordinates
of a structurally related protein, bacteriorhodopsin, were combined to generate a three …