Fork head box O (FOXO) transcription factor is a key player in an evolutionarily conserved
pathway. The mammalian FOXO family consists of FOXO1, 3, 4 and 6, are highly similar in …

Abstract The FoxO family of Forkhead transcription factors plays an important role in
longevity and tumor suppression by upregulating target genes involved in stress resistance …

Several pathologies such as neurodegeneration and cancer are associated with aging,
which is affected by many genetic and environmental factors. Healthy aging conceives …

Members of the class O of forkhead box transcription factors (FOXO) have important roles in
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …

Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …

FOXO (Forkhead box O) transcription factors constitute an evolutionally conserved subgroup
within the large Forkhead family of transcription regulators. FOXO factors are important …

Forkhead box O (FoxO) transcription factors are important downstream targets of the
PI3K/Akt signaling pathway and crucial regulators of cell fate. This function of FoxOs relies …

Abstract The Forkhead box O (FoxO) family has recently been highlighted as an important
transcriptional regulator of crucial proteins associated with the many diverse functions of …

Forkhead box O (FOXO) proteins are a family of transcription factors with four members in
mammals, namely FOXO1, FOXO3a, FOXO4, and FOXO6. FOXO factors, originally identified …

Forkhead box O (FOXO) transcription factors (TFs) are a subclass of the larger family of
forkhead TFs. Mammalians express four members FOXO1, FOXO3, FOXO4, and FOXO6 …