Background Semen quality is negatively correlated with male age and is mainly quantified
by a routine semen analysis, which is descriptive and inconclusive. Sperm proteins or …

Background: Human life without sperm is not possible. Therefore, it is alarming that the
fertilizing ability of human spermatozoa is continuously decreasing. The reasons for that are …

Semen samples from men after a short ejaculatory abstinence show improved sperm quality
and result in increased pregnancy rates, but the underlying mechanisms remain unclear …

Proteomics and metabolomics are emerging as promising tools to investigate the molecular
mechanisms associated with male infertility. Proteins and metabolites play a pivotal role in …

Metabolomics measurements of seminal plasma are widely used in diagnosis and finding of
molecular mechanisms of male infertility. However, so far the limitation of metabolome …

Objective Metabolomic profiling of seminal plasma has been suggested as a possible
approach for a fast and non-invasive male infertility evaluation diagnosis. However …

Aging is associated with structural and functional changes in the organism that result in the
declining of its functioning. Postponed parenthood has renewed the interest in age-related …

Introduction A decrease in sperm cell count has been observed along the last several
decades, especially in the most developed regions of the world. The use of metabolomics to …

In 50% of all infertility cases, the male is subfertile or infertile, however, the underlying
mechanisms are often unknown. Even when assisted reproductive procedures such as in …

Background Male factor is incriminated in approximately 50% of cases of infertility. The
metabolomic approach has recently been used in the assessment of sperm quality and male …