[HTML][HTML] High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser1177 phosphorylation in human aortic …
IP Salt, VA Morrow, FM Brandie, JMC Connell… - Journal of Biological …, 2003 - ASBMB
Recent studies have indicated that insulin activates endothelial nitric-oxide synthase (eNOS)
by protein kinase B (PKB)-mediated phosphorylation at Ser 1177 in endothelial cells …
by protein kinase B (PKB)-mediated phosphorylation at Ser 1177 in endothelial cells …
[HTML][HTML] Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser1179
M Montagnani, H Chen, VA Barr, MJ Quon - Journal of Biological Chemistry, 2001 - ASBMB
Vasodilator actions of insulin are mediated by activation of endothelial nitric-oxide synthase
(eNOS) and subsequent production of NO. Phosphatidylinositol 3-kinase and Akt play …
(eNOS) and subsequent production of NO. Phosphatidylinositol 3-kinase and Akt play …
Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis
SA Ritchie, CF Kohlhaas, AR Boyd, KC Yalla… - Biochemical …, 2010 - portlandpress.com
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-
mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177. In …
mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177. In …
Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells
M Montagnani, LV Ravichandran, H Chen… - Molecular …, 2002 - academic.oup.com
Vasodilator actions of insulin are mediated by signaling pathways involving
phosphatidylinositol 3-kinase (PI 3-kinase) and Akt that lead to activation of endothelial nitric …
phosphatidylinositol 3-kinase (PI 3-kinase) and Akt that lead to activation of endothelial nitric …
Roles for Insulin Receptor, PI3-Kinase, and Akt in Insulin-Signaling Pathways Related to Production of Nitric Oxide in Human Vascular Endothelial Cells
G Zeng, FH Nystrom, LV Ravichandran, LN Cong… - Circulation, 2000 - Am Heart Assoc
Background—Previously, we demonstrated that insulin stimulates production of nitric oxide
(NO) in endothelial cells. However, specific insulin-signaling pathways mediating production …
(NO) in endothelial cells. However, specific insulin-signaling pathways mediating production …
Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin
K Kuboki, ZY Jiang, N Takahara, SW Ha, M Igarashi… - Circulation, 2000 - Am Heart Assoc
Background—The vasodilatory effect of insulin can be acute or increase with time from 1 to 7
hours, suggesting that insulin may enhance the expression of endothelial nitric oxide …
hours, suggesting that insulin may enhance the expression of endothelial nitric oxide …
Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1
Insulin-induced vasodilatation in vivo has been attributed to the activation of the endothelial
nitric oxide (NO) synthase (eNOS). The present study addressed the effects of insulin on the …
nitric oxide (NO) synthase (eNOS). The present study addressed the effects of insulin on the …
Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and …
It has been suggested that serine (Ser) phosphorylation of insulin receptor substrate-1 (IRS-
1) decreases the ability of IRS-1 to be phosphorylated on tyrosine, thereby attenuating …
1) decreases the ability of IRS-1 to be phosphorylated on tyrosine, thereby attenuating …
Protein kinase C-β contributes to impaired endothelial insulin signaling in humans with diabetes mellitus
CE Tabit, SM Shenouda, M Holbrook, JL Fetterman… - Circulation, 2013 - Am Heart Assoc
Background—Abnormal endothelial function promotes atherosclerotic vascular disease in
diabetes. Experimental studies indicate that disruption of endothelial insulin signaling …
diabetes. Experimental studies indicate that disruption of endothelial insulin signaling …
Activation of IKKβ by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells
F Kim, KA Tysseling, J Rice, B Gallis, L Haji… - Journal of molecular and …, 2005 - Elsevier
Hyperglycemic impairment of nitric oxide (NO) production by endothelial cells is implicated
in the effect of diabetes to increase cardiovascular disease risk, but the molecular basis for …
in the effect of diabetes to increase cardiovascular disease risk, but the molecular basis for …