Background Inborn errors of immunity (IEI) are a group of heterogeneous disorders with
geographic and ethnic diversities. Although IEI are common in Egypt, genetic diagnosis is …

Background: Selective IgE deficiency (SIgED) has been previously evaluated in selected
patients from allergy units. This study investigates the effects of SIgED on the entire …

Inborn errors of immunity (IEI) are a heterogeneous group of monogenic disorders that
include primary immunodeficiency's and other disorders affecting different aspects of the …

Background Primary immunodeficiency (PID) disorders are a heterogeneous group of
inherited disorders caused by a variety of monogenetic immune defects. Thus far, mutations …

BACKGROUND: Advances in immunologic techniques in recent years have led to increased
recognition of primary immunodeficiency disorders, with IgA deficiency the most common …

Abstract Background Immunoglobulin E (IgE) deficiency (< 2.5 kU/L) has unclear clinical
significance. Very little is known about the clinical characteristics of IgE deficiency in patients …

With more than 430 genetic defects, primary immunodeficiencies (PIDs) or inborn errors of
immunity are a heterogeneous group of rare genetic disorders affecting the immune system …

Background The number of inherited diseases and the spectrum of clinical manifestations of
primary immunodeficiency disorders (PIDs) are ever-expanding. Molecular diagnosis using …

There are more than 180 different genetic causes of primary immunodeficiencies identified
to date. Approaches for identifying causative mutations can be broadly classified into 3 …

Background Postzygotic de novo mutations lead to the phenomenon of gene mosaicism.
The 3 main types are called somatic, gonadal, and gonosomal mosaicism, which differ in …