O6-Methylguanine-DNA methyltransferase in glioma therapy: Promise and problems
JR Silber, MS Bobola, A Blank… - Biochimica et Biophysica …, 2012 - Elsevier
Gliomas are the most frequent adult primary brain tumor, and are invariably fatal. The most
common diagnosis glioblastoma multiforme (GBM) afflicts 12,500 new patients in the US …
common diagnosis glioblastoma multiforme (GBM) afflicts 12,500 new patients in the US …
MGMT promoter methylation in malignant gliomas
MJ Riemenschneider, ME Hegi, G Reifenberger - Targeted oncology, 2010 - Springer
The O 6-methylguanine-DNA methyltransferase (MGMT) gene is located at chromosome
10q26 and codes for a DNA repair enzyme that—if active—can counteract the effects of …
10q26 and codes for a DNA repair enzyme that—if active—can counteract the effects of …
Correlation of O6-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT …
Resistance to alkylating agents via direct DNA repair by O6-methylguanine
methyltransferase (MGMT) remains a significant barrier to the successful treatment of …
methyltransferase (MGMT) remains a significant barrier to the successful treatment of …
MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma
AL Rivera, CE Pelloski, MR Gilbert, H Colman… - Neuro …, 2010 - academic.oup.com
Hypermethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) gene has been
shown to be associated with improved outcome in glioblastoma (GBM) and may be a …
shown to be associated with improved outcome in glioblastoma (GBM) and may be a …
O6-Methylguanine-DNA Methyltransferase Activity in Adult Gliomas: Relation to Patient and Tumor Characteristics
JR Silber, MS Bobola, S Ghatan, A Blank, DD Kolstoe… - Cancer research, 1998 - AACR
The DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) confers
resistance to therapeutic methylating and chloroethylating agents in human brain tumor …
resistance to therapeutic methylating and chloroethylating agents in human brain tumor …
O 6-Methylguanine-DNA Methyltransferase-deficient Phenotype in Human Gliomas: Frequency and Time to Tumor Progression after Alkylating Agent-based …
JR Silber, A Blank, MS Bobola, S Ghatan… - Clinical cancer …, 1999 - AACR
The DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) contributes to
the resistance of human brain tumor cell lines and xenografts to methylating and …
the resistance of human brain tumor cell lines and xenografts to methylating and …
[HTML][HTML] Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma
OBJECTIVES: 1) To correlate the methylation status of the O 6-methylguanine-DNA-
methyltransferase (MGMT) promoter to its gene and protein expression levels in …
methyltransferase (MGMT) promoter to its gene and protein expression levels in …
O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy
W Yu, L Zhang, Q Wei, A Shao - Frontiers in oncology, 2020 - frontiersin.org
Chemoresistance has been a significant problem affecting the efficacy of drugs targeting
tumors for decades. MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA …
tumors for decades. MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA …
O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas
CH Fan, WL Liu, H Cao, C Wen, L Chen, G Jiang - Cell death & disease, 2013 - nature.com
Temozolomide (TMZ) is an alkylating agent currently used as first-line therapy for gliomas
treatment due to its DNA-damaging effect. However, drug resistance occurs, preventing multi …
treatment due to its DNA-damaging effect. However, drug resistance occurs, preventing multi …
Careful exclusion of non-neoplastic brain components is required for an appropriate evaluation of O6-methylguanine-DNA methyltransferase status in glioma …
K Sasai, M Nodagashira, H Nishihara… - The American journal …, 2008 - journals.lww.com
Abstract Evaluation of O 6-methylguanine-DNA methyltransferase (MGMT) expression is
important for antiglioma therapy as many clinical trials have demonstrated that promoter …
important for antiglioma therapy as many clinical trials have demonstrated that promoter …
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