Murine models of COPD

GG Brusselle, KR Bracke, T Maes, AI D'hulst… - Pulmonary …, 2006 - Elsevier
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation, that is
not fully reversible, and that is associated with an abnormal inflammatory response of the …

Models of chronic obstructive pulmonary disease

DA Groneberg, KF Chung - Respiratory research, 2004 - Springer
Chronic obstructive pulmonary disease (COPD) is a major global health problem and is
predicted to become the third most common cause of death by 2020. Apart from the …

Animal models in chronic obstructive pulmonary disease—an overview

MY Marcelino, NL Fuoco, CA Faria… - Experimental Lung …, 2014 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airway
obstruction resultant from an augmented inflammatory response of the respiratory tract to …

The pathogenesis of COPD: lessons learned from in vivo animal models.

M Fujita, Y Nakanishi - … medical journal of experimental and clinical …, 2007 - europepmc.org
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitations, that
are not fully reversible. COPD is a major cause of chronic morbidity and mortality throughout …

Animal models of chronic obstructive pulmonary disease

PA Dawkins, RA Stockley - Thorax, 2001 - thorax.bmj.com
Chronic obstructive pulmonary disease (COPD) is the fifth leading cause of death in the UK,
1 causing 26 000 deaths and 240 000 hospital admissions and costing the NHS£ 486 …

Animal models of chronic obstructive pulmonary disease: some critical remarks

H Fehrenbach - Pathobiology, 2003 - karger.com
A variety of animal models of chronic obstructive pulmonary disease (COPD) are available,
comprising elastase instillation or inhalation of noxious agents and genetic models like …

The use of transgenic mice for modeling airways disease

SD Shapiro - Pulmonary pharmacology & therapeutics, 2008 - Elsevier
Genetic manipulation in mice often combined with models of human disease has allowed
investigators to dissect specific disease pathways. These tools have taught us much about …

Recent advances in pre-clinical mouse models of COPD

R Vlahos, S Bozinovski - Clinical science, 2014 - portlandpress.com
COPD (chronic obstructive pulmonary disease) is a major incurable global health burden
and will become the third largest cause of death in the world by 2020. It is currently believed …

Chronic obstructive pulmonary disease: evidence for an autoimmune component

AM Stefanska, PT Walsh - Cellular & molecular immunology, 2009 - nature.com
Chronic obstructive pulmonary disease (COPD) is characterized by an irreversible limitation
on pulmonary airflow associated with chronic inflammation and mucous hypersecretion …

Animal models of chronic obstructive pulmonary disease

JL Wright, M Cosio, A Churg - american journal of …, 2008 - journals.physiology.org
The mechanisms involved in the genesis of chronic obstructive pulmonary disease (COPD)
are poorly defined. This area is complicated and difficult to model because COPD consists of …