Environmental enrichment (EE) has been shown to have powerful beneficial effects on a
variety of physiological and pathological processes. Accumulating evidence indicates that …

The impact of stress on brain function is increasingly recognized. Various substances are
released in response to stress and can influence distinct neuronal circuits, but the functional …

Trauma and chronic stress exposure are the strongest predictors of lifetime neuropsychiatric
disease presentation. These disorders often have significant sex biases, with females …

Although anxiety and mood disorders (MDs) are the most common mental diseases, the
etiologies and mechanisms of these psychopathologies are still a matter of debate. The …

One hallmark of psychiatric conditions is the vast continuum of individual differences in
susceptibility vs. resilience resulting from the interaction of genetic and environmental …

The adverse effects of stress on brain and behavior have long been known and well-studied,
with abundant evidence linking stress to, among other things, mood and anxiety disorders …

Early life stress (ELS) induces long-term phenotypic adaptations that contribute to increased
vulnerability to a host of neuropsychiatric disorders. Epigenetic mechanisms, including DNA …

Prolonged or intensive stress results in emotional and cognitive deficits and is a major risk
factor for psychiatric disorders such as depression. Since the molecular mechanisms of how …

Mental health is central to normal health outcomes. A widely accepted theory is that chronic
persistent stress during adulthood as well as during early life triggers onset of …

Stress exposure is associated with individual differences in corticolimbic structure and
function that often mirror patterns observed in psychopathology. Gene x environment …