Neurons in distinct brain regions remodel in response to postnatal stressor exposure, and
structural plasticity may underlie stress-related modifications in behavioral outcomes. Given …

Stress can have a lasting impact on the structure and function of brain circuitry that results in
long-lasting changes in the behavior of an organism. Synaptic plasticity is the mechanism by …

Chronic, unresolved stress is a major risk factor for the development of clinical depression.
While many preclinical models of stress-induced depression have been reported, the …

Enriched environmental (EE) housing dampens stress-induced alterations in
neurobiological systems, promotes adaptability, and extinguishes submissive behavioral …

The adult brain is capable of considerable structural and functional plasticity and the study of
hormone actions in brain has contributed to our understanding of this important …

Although adrenal steroid receptors are distributed widely throughout the central nervous
system, specific limbic and cortical regions targeted by stress hormones play a key role in …

A deeper understanding of the pathomechanisms leading to stress-related psychiatric
disorders is important for the development of more efficient preventive and therapeutic …

Rats are widely used animal models for biological psychiatry and neuroscience. Laboratory
rats are typically housed in impoverished sensory environments. The lack of species-typical …

Stressors differ in their physiological and behavioral outcomes. One of the major
mechanisms by which stressors affect the brain and behavior is alteration in neuronal …

Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …