Historically, most pharmacological approaches to the treatment of addictive disorders have
utilized either substitution-based methods (ie, nicotine replacement or opioid maintenance) …

Historically, most pharmacological approaches to the treatment of addictive disorders have
utilized either substitution-based methods (ie, nicotine replacement or opioid maintenance) …

The past decade has witnessed a growing body of preclinical and clinical evidence that
glutamatergic systems may play a pivotal role in drug dependence. In Glutamate and …

Considerable research into the neurobiology of cocaine addiction has shed light on the role
of glutamate. Findings from models of relapse to cocaine-seeking indicate that the …

Traditionally, theories of dopamine reward (Wise 1996; Wise and Bozarth 1987) dominated
the field of alcohol and substance use disorder. The brain's most abundant neurotransmitter …

Historically, brain catecholamine systems have been the primary focus of studies examining
the neural substrates of drug addiction. In the past two decades, however, a wealth of …

Glutamate is the principal excitatory neurotransmitter in the central nervous system, playing
an essential role in virtually every brain system and their associated behavioral functions …

The development of new treatments for substance use disorders requires identification of
targetable molecular mechanisms. Pathology in glutamatergic neurotransmission system in …

The prevalence and impact of drug addiction on society are staggering. The abuse of
alcohol, tobacco, and illicit drugs accounts for approximately 10% of the global burden of …

Cortico-striatal glutamate transmission has been implicated in both the initiation and
expression of addiction related behaviors, such as locomotor sensitization and drug …