Toward the clinical application of time-domain fluorescence lifetime imaging

I Munro, J McGinty, N Galletly… - Journal of …, 2005 - spiedigitallibrary.org
High-speed (video-rate) fluorescence lifetime imaging (FLIM) through a flexible endoscope
is reported based on gated optical image intensifier technology. The optimization and …

Real-time time-domain fluorescence lifetime imaging including single-shot acquisition with a segmented optical image intensifier

DS Elson, I Munro, J Requejo-Isidro… - New Journal of …, 2004 - iopscience.iop.org
Abstract High-speed (video-rate) fluorescence lifetime imaging (FLIM) is reported using two
different time-domain approaches based on gated optical image intensifier technology. The …

High resolution time-domain fluorescence lifetime imaging for biomedical applications

K Dowling, MJ Dayel, SCW Hyde… - Journal of Modern …, 1999 - Taylor & Francis
We report the development of a whole-field fluorescence lifetime imaging (FLIM) system with
high temporal resolution based on a time-gated image intensifier. The optimized temporal …

Biomedical applications of fluorescence lifetime imaging

D Elson, S Webb, J Siegel, K Suhling… - Optics and photonics …, 2002 - opg.optica.org
Biomedical Applications of Fluorescence Lifetime Imaging Page 1 Dan Elson, Stephen
Webb, Jan Siegel, Klaus Suhling, Dan Davis, John Lever, David Phillips, Andrew Wallace …

[HTML][HTML] Flexible endoscope for continuous in vivo multispectral fluorescence lifetime imaging

S Cheng, JJ Rico-Jimenez, J Jabbour, B Malik… - Optics …, 2013 - pmc.ncbi.nlm.nih.gov
Fluorescence lifetime imaging (FLIM) offers a noninvasive approach for characterizing the
biochemical composition of biological tissue. There has been an increasing interest in the …

Time-domain fluorescence lifetime imaging applied to biological tissue

D Elson, J Requejo-Isidro, I Munro, F Reavell… - Photochemical & …, 2004 - Springer
Fluorescence lifetime imaging (FLIM) is a functional imaging methodology that can provide
information, not only concerning the localisation of specific fluorophores, but also about the …

Wide-field fluorescence lifetime imaging of cancer

J McGinty, NP Galletly, C Dunsby, I Munro… - Biomedical optics …, 2010 - opg.optica.org
Optical imaging of tissue autofluorescence has the potential to provide rapid label-free
screening and detection of surface tumors for clinical applications, including when combined …

Fluorescence lifetime imaging with picosecond resolution for biomedical applications

K Dowling, MJ Dayel, MJ Lever, PMW French… - Optics letters, 1998 - opg.optica.org
We describe a novel whole-field fluorescence lifetime imaging system, based on a time-
gated image intensifier and a solid-state laser oscillator–amplifier, that images lifetime …

Handheld multispectral fluorescence lifetime imaging system for in vivo applications

S Cheng, RM Cuenca, B Liu, BH Malik… - Biomedical optics …, 2014 - opg.optica.org
There is an increasing interest in the application of fluorescence lifetime imaging (FLIM) for
medical diagnosis. Central to the clinical translation of FLIM technology is the development …

A flexible wide‐field FLIM endoscope utilising blue excitation light for label‐free contrast of tissue

H Sparks, S Warren, J Guedes, N Yoshida… - Journal of …, 2015 - Wiley Online Library
Fluorescence lifetime imaging (FLIM) has previously been shown to provide contrast
between normal and diseased tissue. Here we present progress towards clinical and …