Distinct genetic subtypes of adiposity and glycemic changes in response to weight-loss diet intervention: the POUNDS Lost trial

Y Chen, T Zhou, D Sun, X Li, H Ma, Z Liang… - European journal of …, 2021 - Springer
Purpose Obesity is a heterogeneous condition and distinct adiposity subtypes may
differentially affect type 2 diabetes risk. We assessed relations between genetically …

Genetic variation of fasting glucose and changes in glycemia in response to 2-year weight-loss diet intervention: the POUNDS LOST trial

T Wang, T Huang, Y Zheng, J Rood, GA Bray… - International journal of …, 2016 - nature.com
Objective: Weight-loss intervention through diet modification has been widely used to
improve obesity-related hyperglycemia; however, little is known about whether genetic …

Genetic predictors of change in waist circumference and waist-to-hip ratio with lifestyle intervention: The trans-nih consortium for genetics of weight loss response to …

JM McCaffery, KA Jablonski, Q Pan, A Astrup… - Diabetes, 2022 - Am Diabetes Assoc
Genome-wide association studies have identified single nucleotide polymorphisms (SNPs)
associated with waist circumference (WC) and waist-to-hip ratio (WHR) adjusted for BMI …

The Personalized Nutrition Study (POINTS): evaluation of a genetically informed weight loss approach, a Randomized Clinical Trial

C Höchsmann, S Yang, JM Ordovás, JL Dorling… - Nature …, 2023 - nature.com
Weight loss (WL) differences between isocaloric high-carbohydrate and high-fat diets are
generally small; however, individual WL varies within diet groups. Genotype patterns may …

[HTML][HTML] Effect of low-fat vs low-carbohydrate diet on 12-month weight loss in overweight adults and the association with genotype pattern or insulin secretion: the …

CD Gardner, JF Trepanowski, LC Del Gobbo… - Jama, 2018 - jamanetwork.com
Importance Dietary modification remains key to successful weight loss. Yet, no one dietary
strategy is consistently superior to others for the general population. Previous research …

[HTML][HTML] Genetic susceptibility to diabetes and long-term improvement of insulin resistance and β cell function during weight loss: the Preventing Overweight Using …

T Huang, SH Ley, Y Zheng, T Wang, GA Bray… - The American Journal of …, 2016 - Elsevier
Background: Diet interventions have shown effectiveness in improving diabetes risk factors;
however, little is known about whether the effects of diet intervention are different according …

Genetic risk scores for body fat distribution attenuate weight loss in women during dietary intervention

M Svendstrup, KH Allin, TIA Sørensen… - International Journal of …, 2018 - nature.com
Objective: The well-established link between body fat distribution and metabolic health has
been suggested to act through an impact on the remodeling capacity of the adipose tissue …

Genetic variation in lean body mass, changes of appetite and weight loss in response to diet interventions: The POUNDS Lost trial

X Li, T Zhou, H Ma, Y Heianza… - Diabetes, Obesity …, 2020 - Wiley Online Library
Aim To investigate whether the genetic risk score (GRS) for lean body mass (LBM) modified
the effects of weight‐loss diets on changes in appetite and adiposity among overweight and …

Genetic predisposition to weight loss and regain with lifestyle intervention: analyses from the Diabetes Prevention Program and the Look AHEAD randomized …

GD Papandonatos, Q Pan, NM Pajewski… - Diabetes, 2015 - Am Diabetes Assoc
Clinically relevant weight loss is achievable through lifestyle modification, but unintentional
weight regain is common. We investigated whether recently discovered genetic variants …

Abdominal obesity genetic variants predict waist circumference regain after weight loss

MR Christiansen, TO Kilpeläinen, JM McCaffery - Diabetes, 2023 - Am Diabetes Assoc
Although many individuals are able to achieve weight loss, maintaining this loss over time is
challenging. We aimed to study whether genetic predisposition to general or abdominal …