Combination therapy is necessary to treat tuberculosis to decrease the rate of disease
relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently …

Effective tuberculosis treatment requires at least 6 months of combination therapy.
Alterations in the physiological state of the bacterium during infection are thought to reduce …

In the face of the unrelenting global burden of tuberculosis (TB), antibiotics remain our most
effective tools to save lives and control the spread of Mycobacterium tuberculosis (Mtb) …

Tuberculosis still remains a global health emergency, claiming 1.5 million lives in 2013. The
bacterium responsible for this disease, Mycobacterium tuberculosis (M. tb), has successfully …

The increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished
the efficacy of almost all available antibiotics, complicating efforts to combat the spread of …

Combination therapy has, to some extent, been successful in limiting the emergence of drug-
resistant tuberculosis. Drug combinations achieve this advantage by simultaneously acting …

Recent worldwide emergence of multidrug-resistant and extensively drug-resistant
tuberculosis is threatening to destabilize tuberculosis control programs and urging global …

Antibiotics have played a crucial role in the reduction in the incidence of TB globally as
evidenced by the fact that before the mid-20th century, the mortality rate within five years of …

There is an urgent need to improve methods used to screen antituberculosis drugs. An in
vitro assay was developed to test drug treatment strategies that specifically target drug …

Successful treatment of tuberculosis (TB) depends on the eradication of its causative agent
Mycobacterium tuberculosis (Mtb) in the host. However, the emergence of phenotypically …