The microvasculature is a key interface between blood and tissues and participates in
numerous pathophysiological processes. The heterogeneity of microvascular endothelial …

The pancreatic islets are one of the most vascularized organs of the body. This likely reflects
the requirements of the organ for a rich supply of nutrients and oxygen to the tissue, as well …

Microvascular development is determined by the interplay between tissue cells and
microvascular endothelial cells. Because the pancreatic islet is an organ composed mainly …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

The pancreatic islet is highly vascularised, with an extensive capillary network. In addition to
providing nutrients and oxygen to islet endocrine cells and transporting hormones to the …

The intra-islet microvasculature is a critical interface between the blood and islet endocrine
cells governing a number of cellular and pathophysiological processes associated with the …

Pancreatic islets are clusters of endocrine cells that secrete different hormones to regulate
blood glucose levels. Efficient hormone secretion requires a close interaction of endocrine …

Islet microvasculature provides key architectural and functional roles, yet the morphological
features of islets from patients with type 1 diabetes are poorly defined. We examined islet …

The endocrine and exocrine pancreas have been studied separately by endocrinologists
and gastroenterologists as two organ systems. The pancreatic islet, consisting of 1–2 …

Pancreatic islets adapt to insulin resistance through a complex set of changes, including β-
cell hyperplasia and hypertrophy. To determine if islet vascularization changes in response …