The islets of Langerhans consist of endocrine cells embedded in a network of specialized
capillaries that regulate islet blood flow. Despite evidence for a critical role of islet perfusion …

Aims/hypothesis Islet vascular fibrosis may play an important role in the progression of type
2 diabetes, but there are no mouse models allowing detailed mechanistic studies to …

Efficient insulin secretion requires a well-functioning pancreatic islet microvasculature. The
dense network of islet capillaries includes the islet pericyte, a cell that has barely been …

The vascular network supporting the islets of Langerhans represents a highly specialised
system of arterioles, capillaries and venules. Several features of the islet vasculature …

The vascular supply is of crucial importance for endocrine organs since the
microvasculature, in addition to supplying oxygen and nutrients, is initially responsible for …

Islet transplantation has become a widely accepted therapeutic option for selected patients
with type 1 diabetes mellitus. However, in order to achieve insulin independence a great …

Pancreatic islet transplantation is an emerging therapy for type 1 diabetes. To survive and
function, transplanted islets must revascularize because islet isolation severs arterial and …

Human and rodent islets differ substantially in several features, including architecture, cell
composition, gene expression and some aspects of insulin secretion. Mouse pancreatic …

Pancreatic islet transplantation has emerged as a therapy for type 1 diabetes and is today
performed using both freshly isolated and cultured islets. Islet blood vessels are disrupted …

Pancreatic islets are endocrine organs that depend on their microvasculature to function.
Along with endothelial cells, pericytes comprise the islet microvascular network. These …