Endothelial cells (ECs) are essential for pancreas differentiation, endocrine specification,
and endocrine function. They are also involved in the physiopathology of type 1 and type 2 …

Pancreatic islet transplantation is a promising therapy to regain glycemic control in diabetic
patients. The selection of ideal grafts is the basis to guarantee short‐term effectivity and …

Understanding the organisation and role of the extracellular matrix (ECM) in islets of
Langerhans is critical for maintaining pancreatic β‐cells, and to recognise and revert the …

Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for
coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult …

Blood vessel endothelium has been recently shown to induce endocrine pancreatic
development [1]. Because pancreatic endocrine cells or islets express high levels of …

Clinical treatment of diabetic patients by islet transplantation faces various complications. At
present, in vitro expansion of islets occurs at the cost of their essential features, which are …

β-Cells respond to peripheral insulin resistance by first increasing circulating insulin during
diabetes. Islet remodeling supports this compensation, but its drivers remain poorly …

To discuss the controversy of the current concept of islet microcirculation, an international
symposium was held at the Long Beach Veterans Administration Regional Medical …

The blood vessels of the pancreatic islets are of crucial importance for oxygen and
metabolite supply, and dispersal of secreted hormones. In addition to this, endothelial cells …

Owing to strong interactions between pancreatic islets and the surrounding capillary
network, we hypothesized that high glucose concentrations might affect key angiogenesis …