An increasing number of studies have demonstrated that disease states of the endocrine or
exocrine pancreas aggravate one another, which implies bidirectional blood flow between …

Type 1 diabetes is characterized by a mononuclear infiltration, commonly called" insulitis".
The cells that constitute the insulitis are mainly monocytes that are recruited from extra-islet …

Pancreatic β-cells modulate insulin secretion through rapid sensing of blood glucose and
integration of gut-derived signals. Increased insulin demand during pregnancy and obesity …

Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor
(VEGF)-A is a critical factor in the development of islet vascularization. To investigate the …

Because of our shared interest in islet biology, we have read the article by Weir and Bonner-
Weir (1) in this issue of Diabetes with great interest. Recent in vitro and in vivo studies …

Aims/hypothesis Based on mouse study findings, pancreatic islet cells are supposed to lack
basement membrane (BM) and interact directly with vascular endothelial BM. Until now, the …

The vasculature of the islets of Langerhans was studied in rats using methacrylate corrosion
casts and islet reconstructions from stained serial paraffin sections. In corrosion casts, which …

The vascular endothelium has been identified as an important component in diabetes-
associated complications, which include many cardiovascular disorders such as …

Although the microvascular endothelium has been identified as the primary target site for the
initiation of pancreatic islet graft rejection, little is known of the microvascular and cellular …

Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular
endothelial growth factor-A (VEGF-A) signaling are important for islet differentiation and the …