Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in human atherosclerotic lesions

DY Li, HJ Chen, ED Staples, K Ozaki… - Journal of …, 2002 - journals.sagepub.com
Background: Lectin-like oxidized LDL receptor-I (LOX-1), a novel receptor for oxidized low-
density lipoprotein, mediates oxidized low-density lipoprotein-induced apoptosis of …

Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from …

D Li, JL Mehta - Arteriosclerosis, thrombosis, and vascular biology, 2000 - Am Heart Assoc
A specific lectinlike endothelial receptor for oxidized low density lipoprotein (LOX-1), distinct
from the scavenger receptor in monocytes/macrophages, has been identified and cloned. In …

Prominent lectin-like oxidized low density lipoprotein (LDL) receptor-1 (LOX-1) expression in atherosclerotic lesions is associated with tissue factor expression and …

Y Kuge, N Kume, S Ishino, N Takai… - Biological and …, 2008 - jstage.jst.go.jp
Background: Despite increasing in vitro evidence that lectin-like oxidized low density
lipoprotein (LDL) receptor-1 (LOX-1), a cell-surface receptor for oxidized LDL, is implicated …

LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis

M Chen, T Masaki, T Sawamura - Pharmacology & therapeutics, 2002 - Elsevier
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) was initially identified
as the major receptor for oxidized LDL (OxLDL) in endothelial cells. Its inducible expression …

Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders

JL Mehta, J Chen, PL Hermonat, F Romeo… - Cardiovascular …, 2006 - academic.oup.com
Abstract LOX-1, a lectin-like 52-kD receptor for oxidized low-density lipoproteins (ox-LDL), is
present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by …

Apoptosis of vascular cells by oxidized LDL: involvement of caspases and LOX-1 and its implication in atherosclerotic plaque rupture

N Kume, T Kita - Circulation research, 2004 - Am Heart Assoc
Atherosclerotic plaque rupture followed by thrombus formation is a key event in the onset of
acute coronary syndrome. 1 Apoptotic death of smooth muscle cells in the fibrous cap of the …

LOX-1 pathway affects the extent of myocardial ischemia-reperfusion injury

K Kataoka, K Hasegawa, T Sawamura, M Fujita… - Biochemical and …, 2003 - Elsevier
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) was originally identified as a
receptor for oxidized low-density lipoprotein predominantly expressed in endothelial cells …

[HTML][HTML] The discovery of LOX-1, its ligands and clinical significance

R Yoshimoto, Y Fujita, A Kakino, S Iwamoto… - … drugs and therapy, 2011 - Springer
LOX-1 is an endothelial receptor for oxidized low-density lipoprotein (oxLDL), a key
molecule in the pathogenesis of atherosclerosis. The basal expression of LOX-1 is low but …

Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions

H Kataoka, N Kume, S Miyamoto, M Minami… - Circulation, 1999 - Am Heart Assoc
Background—Oxidized LDL (Ox-LDL) seems to play key roles in atherogenesis. Lectinlike
Ox-LDL receptor-1 (LOX-1) is a recently identified cell-surface receptor for Ox-LDL. The …

Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation

M Honjo, K Nakamura, K Yamashiro… - Proceedings of the …, 2003 - National Acad Sciences
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a major endothelial
receptor for oxidized low-density lipoprotein, and is assumed to play a proatherogenic role …