Essential protein detection by random walk on weighted protein-protein interaction networks

B Xu, J Guan, Y Wang, Z Wang - IEEE/ACM Transactions on …, 2017 - ieeexplore.ieee.org
Essential proteins are critical to the development and survival of cells. Identification of
essential proteins is helpful for understanding the minimal set of required genes in a living …

Random walk based method to identify essential proteins by integrating network topology and biological characteristics

X Lei, X Yang, H Fujita - Knowledge-Based Systems, 2019 - Elsevier
Essential proteins are regarded as the fundamental components of living organisms. The
identification of essential proteins greatly contributes to the understanding of cellular …

A seed expansion-based method to identify essential proteins by integrating protein–protein interaction sub-networks and multiple biological characteristics

H Zhao, G Liu, X Cao - BMC bioinformatics, 2023 - Springer
Background The identification of essential proteins is of great significance in biology and
pathology. However, protein–protein interaction (PPI) data obtained through high …

Detecting essential proteins based on network topology, gene expression data, and gene ontology information

W Zhang, J Xu, Y Li, X Zou - IEEE/ACM transactions on …, 2016 - ieeexplore.ieee.org
The identification of essential proteins in protein-protein interaction (PPI) networks is of great
significance for understanding cellular processes. With the increasing availability of large …

A random walk-based method for detecting essential proteins by integrating the topological and biological features of PPI network

NM Ahmed, L Chen, B Li, W Liu, C Dai - Soft Computing, 2021 - Springer
The essential protein detection on protein–protein interaction (PPI) network can not only
promote the research of life science, but also have important applications in disease …

A new method for the discovery of essential proteins

X Zhang, J Xu, W Xiao - PloS one, 2013 - journals.plos.org
Background Experimental methods for the identification of essential proteins are always
costly, time-consuming, and laborious. It is a challenging task to find protein essentiality only …

Identifying essential proteins from active PPI networks constructed with dynamic gene expression

Q Xiao, J Wang, X Peng, F Wu, Y Pan - BMC genomics, 2015 - Springer
Essential proteins are vitally important for cellular survival and development, and identifying
essential proteins is very meaningful research work in the post-genome era. Rapid increase …

Essential protein recognition via community significance

Y Liu, W Chen, Z He - IEEE/ACM Transactions on …, 2021 - ieeexplore.ieee.org
Essential protein plays a vital role in understanding the cellular life. With the advance in high-
throughput technologies, a number of protein-protein interaction (PPI) networks have been …

Identification of essential proteins based on edge clustering coefficient

J Wang, M Li, H Wang, Y Pan - IEEE/ACM Transactions on …, 2011 - ieeexplore.ieee.org
Identification of essential proteins is key to understanding the minimal requirements for
cellular life and important for drug design. The rapid increase of available protein-protein …

Identification of essential proteins based on ranking edge-weights in protein-protein interaction networks

Y Wang, H Sun, W Du, E Blanzieri, G Viero, Y Xu… - PloS one, 2014 - journals.plos.org
Essential proteins are those that are indispensable to cellular survival and development.
Existing methods for essential protein identification generally rely on knock-out experiments …