The work presented here represents three separate research projects. Each explores
different approaches to the same problem: how can artificial macromolecules be used to …

The design, synthesis and properties of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers as carriers of anticancer drugs are reviewed. Macromolecular therapeutics …

Synthetic strategies and chemical and structural aspects of the synthesis of HPMA
copolymer conjugates with various drugs and other biologically active molecules are …

Highlights•HPMA (N-2-hydroxypropylmethacrylamide) is an emerging polymeric alternative
for drug delivery applications.•HPMA can be potentially conjugated to develop copolymers …

Over the past few decades, numerous polymer drug carrier systems are designed and
synthesized, and their properties are evaluated. Many of these systems are based on water …

The concept of polymer–drug conjugates was proposed more than 30 years ago, and an N-
(2-hydroxypropyl) methacrylamide (HPMA) copolymer conjugate of doxorubicin covalently …

During last three decades, a great effort was invested to the development of polymer
conjugates of low molecular drugs with the aim to improve the specific targeting of drugs to …

Copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) are prototypic and well-
characterized polymeric drug carriers that are being broadly implemented in the delivery of …

Marriage of cell biology (the concept of 'lysosomotropic drug delivery') and the realization
that water-soluble synthetic polymers might provide an ideal platform for targeted drug …

In recent years, polymer drug carriers based on N-(2-hydroxypropyl) methacrylamide
(HPMA) copolymers with pH-triggered drug release have shown enhanced uptake in solid …