Diabetes is a major contributing factor in cataract development. In animal models where
cataracts develop within days or weeks of diabetes it is well established that osmotic stress …

Purpose Hydrogen peroxide (H 2 O 2) is an endogenously produced reactive oxygen
species (ROS) present in a variety of mammalian systems. This particular ROS can play …

Purpose.: Previous experiments showed that mouse lenses have an intracellular hydrostatic
pressure that varied from 335 mm Hg in central fibers to 0 mm Hg in surface cells. Model …

Previous studies from this laboratory have shown that the normal lens can tolerate exposure
to 0· 05 m MH 2 O 2 without apparent damage and that this is due in part to an active …

• We investigated the cytotoxicity of hydrogen peroxide by exposing primary cell cultures of
human corneal epithelium to a single dose of this agent at concentrations ranging from 30 to …

The effect of comparable concentrations of H2O2 and tertiary butyl hydroperoxide (TBHP)
upon an immortal murine lens epithelial cell line was examined as part of an ongoing effort …

An in vitro animal model was used to characterize the protective effect of glucose on lenses
subjected to oxidative stress. Paired rat lenses were incubated in TC-199 medium for six …

The corneal epithelium can be affected adversely by some preservatives used in contact
lens solutions. To test the effect of H 2 O 2 at the epithelial surface, the rabbit cornea was …

Molecular oxygen is a primary oxidant that is involved in the formation of active oxygen
species and in the oxidation of lipids and proteins. Thus, controlling oxygen partial pressure …

Our previous studies have shown that exposure of cultured rabbit lenses to physiological
levels of hydrogen peroxide, following inhibition of the glutathione redox cycle, leads to the …