Healthy skeletal muscle possesses the extraordinary ability to regenerate in response to
small‐scale injuries; however, this self‐repair capacity becomes overwhelmed with aging …

Skeletal muscle possesses remarkable plasticity that permits functional adaptations to a
wide range of signals such as motor input, exercise, and disease. Small animal models have …

Highlights•Animal models can be poor mimics of healthy and diseased skeletal muscle
phenotypes.•Engineered muscle tissues offer alternative systems to study dystrophic …

Skeletal muscle is the largest organ of human body with several important roles in everyday
movement and metabolic homeostasis. The limited ability of small animal models of muscle …

Introduction With the advances in skeletal muscle tissue engineering, new platforms have
arisen with important applications in biology studies, disease modeling, and drug testing …

Skeletal muscle is a complex tissue composed of multinucleated myofibers responsible for
force generation that are supported by multiple cell types. Many severe and lethal disorders …

Generating human skeletal muscle models is instrumental for investigating muscle
pathology and therapy. Here, we report the generation of three-dimensional (3D) artificial …

Advanced in vitro models of human skeletal muscle tissue are increasingly needed to model
complex developmental dynamics and disease mechanisms not recapitulated in animal …

For over two decades, research groups have been developing methods to engineer three-
dimensional skeletal muscle tissues. These tissues hold great promise for use in disease …

Tissue-engineered skeletal muscle has the promise to be a tool for studying physiology,
screening muscle-active drugs, and clinical replacement of damaged muscle. To maximize …