Mechanisms and consequences of positive-strand RNA virus recombination

K Bentley, DJ Evans - Journal of General Virology, 2018 - microbiologyresearch.org
Genetic recombination in positive-strand RNA viruses is a significant evolutionary
mechanism that drives the creation of viral diversity by the formation of novel chimaeric …

Evolutionary aspects of recombination in RNA viruses

M Worobey, EC Holmes - Journal of General Virology, 1999 - microbiologyresearch.org
RNA viruses deserve their reputation as Nature's swiftest evolvers. Their high rates of
mutation and replication (Holland et al., 1982) allow them to move through sequence space …

Why do RNA viruses recombine?

E Simon-Loriere, EC Holmes - Nature Reviews Microbiology, 2011 - nature.com
Recombination occurs in many RNA viruses and can be of major evolutionary significance.
However, rates of recombination vary dramatically among RNA viruses, which can range …

Recombination in positive-strand RNA viruses

H Wang, X Cui, X Cai, T An - Frontiers in microbiology, 2022 - frontiersin.org
RNA recombination is a major driver of genetic shifts tightly linked to the evolution of RNA
viruses. Genomic recombination contributes substantially to the emergence of new viral …

Nonreplicative homologous RNA recombination: promiscuous joining of RNA pieces?

AP Gmyl, SA Korshenko, EV BELOUSOV, EV Khitrina… - Rna, 2003 - rnajournal.cshlp.org
Biologically important joining of RNA pieces in cells, as exemplified by splicing and some
classes of RNA editing, is posttranscriptional, whereas in RNA viruses it is generally …

Paradoxes of the replication of picornaviral genomes

VI Agol, AV Paul, E Wimmer - Virus research, 1999 - Elsevier
A wealth of experimental data on the mechanism of the picornavirus genome replication has
accumulated. Not infrequently, however, conclusions derived from these data appear to …

Frequent homologous recombination events between molecules of one RNA component in a multipartite RNA virus

A Bruyere, M Wantroba, S Flasinski, A Dzianott… - Journal of …, 2000 - Am Soc Microbiol
Brome mosaic bromovirus (BMV), a tripartite plus-sense RNA virus, has been used as a
model system to study homologous RNA recombination among molecules of the same RNA …

The polymerase in its labyrinth: mechanisms and implications of RNA recombination

TC Jarvis, K Kirkegaard - Trends in Genetics, 1991 - Elsevier
The wide variety of RNA viruses, and the diseases associated with them, may result in part
from the capacity of RNA genomes to evolve through genetic recombination. Here we …

New insights into the mechanisms of RNA recombination

PD Nagy, AE Simon - Virology, 1997 - Elsevier
RNA plays many different roles in biological systems. characteristic marker mutations from
the parental RNAs. One of RNAs most intriguing features is the ability to Following the initial …

Genome-wide screen identifies host genes affecting viral RNA recombination

E Serviene, N Shapka, CP Cheng… - Proceedings of the …, 2005 - National Acad Sciences
Rapid evolution of RNA viruses with mRNA-sense genomes is a major concern to health
and economic welfare because of the devastating diseases these viruses inflict on humans …