Advanced staged high‐grade serous ovarian cancer (HGSOC) is the leading cause of
gynecological cancer death in the developed world, with 5‐year survival rates of only 25 …

Nano-drug delivery holds great potential to enhance the efficacy of carboplatin. This study
focused on cytotoxicity, in vitro drug release and characterization of poly (butyl …

Background: This study aimed to develop a novel drug formulation using
polybutylcyanoacrylate (PBCA) nanoparticles to deliver cisplatin, a commonly used …

Novel paclitaxel‐loaded polymer nanoparticles were developed for circumventing multidrug
resistance (MDR) of malignant cancerous diseases, which is an unsolved clinical problem in …

Overexpression of P-glycoprotein (P-gp) is a key factor contributing to the development of
multidrug resistance (MDR) in cancer cells. The objective of the study is to investigate …

Purpose: To modulate intracellular ceramide levels and lower the apoptotic threshold in
multidrug-resistant ovarian adenocarcinoma, we have examined the efficacy and …

Background Ovarian cancer is the most leading cause of death and the third most common
gynecologic malignancy in women. Traditional chemotherapy has inevitable drawbacks of …

The combination of chemotherapy drugs and multidrug-resistant reversing agents for
treating multidrug resistance in tumors has attracted increasing attention. However, the poor …

Ovarian cancer (OvCa) is currently the fifth most lethal malignancy affecting women health
owing to the lack of early diagnosis and treatment choices available before the disease has …

Objective: Most primary human ovarian tumors and peritoneal implants, as well as tumor
vascular endothelial cells, express the CD44 family of cell surface proteoglycans, the natural …