Nanomedicines have become an attractive platform for the development of novel drug
delivery systems in cancer chemotherapy. Polymeric nanoparticles (NPs) represent one of …

Multidrug resistance (MDR) of tumor cells is a major obstacle to the success of cancer
chemotherapy. Poloxamers have been used in cancer therapy to overcome MDR. The …

The overexpression of permeability-glycoprotein (P-gp), an ABC transporter involved in the
cellular exclusion of chemotherapeutic drugs, is a major factor in paclitaxel-resistant ovarian …

Objective The development of multidrug resistance (MDR) remains the significant clinical
challenge in ovarian cancer therapy; however, relatively little is known about how to prevent …

Breast cancer is the most common cancer and the second cause of cancer‐related death in
women worldwide. Chemotherapy of disease is impeded by subsequent relapse and …

The present study was designed to explore the ability of polymeric nanoparticles to restore
drug sensitivity to P-glycoprotein over-expressing cancer cells. A multidrug-resistant cell line …

Strategies to prevent the emergence of drug resistance will increase the effectiveness of
chemotherapy treatment and prolong survival of women with ovarian cancer. The aim of our …

Background Cisplatin is a potent anticancer drug, but its clinical application has been limited
due to its undesirable physicochemical characteristics and severe side effects. Better drug …

Paclitaxel (PTX) is one of the most effective drugs for treating a variety of solid tumors. Due
to its poor aqueous solubility, Cremophor EL is used as solvent for its marketed formulation …

Multidrug resistance (MDR) is one of the major obstacles to successful chemotherapy.
Overexpression of drug efflux transporters such as P-glycoprotein (P-gp) is an important …