As successful chemotherapy with the taxanes needs to reduce the toxic side effects against
normal tissues and avoid the detrimental effects caused by intolerable solvents, drug …

Carboplatin is a chemotherapeutic agent used against various malignancies such as
ovarian carcinoma. The aim of this study is to improve the therapeutic efficacy of carboplatin …

Purpose Patients with recurrent ovarian, peritoneal, or fallopian tube cancer have limited
therapeutic options. There are no reports of nanoparticle albumin–bound paclitaxel (nab …

Development of drug resistance is a central challenge to the treatment of ovarian cancer.
Metronomic chemotherapy decreases the extent of drug-free periods, thereby hindering …

Background Multidrug resistance remains a major obstacle to successful cancer
chemotherapy. Some chemical multidrug resistance inhibitors, such as ciclosporin and …

The objectives of this study were to evaluate the potential of a polymer-lipid hybrid
nanoparticle (PLN) system to enhance cellular accumulation and retention of doxorubicin …

Chemotherapy is commonly used in the treatment of ovarian cancer, yet most ovarian
cancers harbor inherent resistance or develop acquired resistance. Therefore, novel …

Background: Nanoparticles are under investigation as carrier systems for anticancer drugs.
The expression of efflux transporters such as the ATP-binding cassette (ABC) transporter …

Paclitaxel (PTX) is a microtubule inhibitor administered as an albumin-bound
nanoformulation for the treatment of breast cancer. However, the effectiveness of PTX is …

Overcoming multidrug resistance (MDR) in cancer is a major challenge and efforts are on-
going to develop inhibitors against the most characterized and ubiquitous MDR transporters …