The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an …

YL Boteon, RW Laing, A Schlegel, L Wallace, A Smith… - PLoS …, 2019 - journals.plos.org
Introduction The combination of hypothermic and normothermic machine perfusion (HMP+
NMP) of the liver provides individual benefits of both techniques, improving the rescue of …

An oxygenated and transportable machine perfusion system fully rescues liver grafts exposed to lethal ischemic damage in a pig model of DCD liver transplantation

P Compagnon, E Levesque, H Hentati… - …, 2017 - journals.lww.com
Background Control of warm ischemia (WI) lesions that occur with donation after circulatory
death (DCD) would significantly increase the donor pool for liver transplantation. We aimed …

Computational prediction of mechanical hemolysis in aortic valved prostheses

MD De Tullio, J Nam, G Pascazio, E Balaras… - European Journal of …, 2012 - Elsevier
The paper reports the prediction of mechanical hemolysis by three different models for the
case of blood flow through aortic valved prostheses. Two of the adopted models are based …

Influence of oxygen concentration during hypothermic machine perfusion on porcine kidneys from donation after circulatory death

DP Hoyer, A Gallinat, S Swoboda… - …, 2014 - journals.lww.com
Background Hypothermic machine perfusion (HMP) for preservation led to compelling
success for outcomes of renal transplantation. Application of different concentrations of …

Attempt to rescue discarded human liver grafts by end ischemic hypothermic oxygenated machine perfusion

K Vekemans, J Van Pelt, M Komuta, T Wylin… - Transplantation …, 2011 - Elsevier
In a porcine liver transplant model, a brief period of oxygenated hypothermic machine
perfusion (HMP) at the end of simple cold storage (SCS) has been shown to improve the …

Prediction of mechanical hemolysis in medical devices via a Lagrangian strain‐based multiscale model

M Nikfar, M Razizadeh, J Zhang, R Paul, ZJ Wu… - Artificial …, 2020 - Wiley Online Library
This work introduces a new Lagrangian strain‐based model to predict the shear‐induced
hemolysis in biomedical devices. Current computational models for device‐induced …

Evaluation of shear stress accumulation on blood components in normal and dysfunctional bileaflet mechanical heart valves using smoothed particle hydrodynamics

S Shahriari, H Maleki, I Hassan, L Kadem - Journal of biomechanics, 2012 - Elsevier
Evaluating shear induced hemodynamic complications is one of the major concerns in
design of the mechanical heart valves (MHVs). The monitoring of these events relies on both …

[HTML][HTML] Extended hypothermic oxygenated machine perfusion enables ex situ preservation of porcine livers for up to 24 hours

IMA Brüggenwirth, OB van Leeuwen, Y de Vries… - JHEP Reports, 2020 - Elsevier
Background & Aims End-ischemic hypothermic oxygenated machine perfusion (HOPE) of
the donor liver for 1–2 h mitigates ischemia-reperfusion injury during subsequent liver …

Hypothermic machine perfusion of kidney grafts: which pressure is preferred?

BM Doorschodt, M Schreinemachers… - Annals of biomedical …, 2011 - Springer
To assess the effect of the perfusion pressure (PP) during machine perfusion (MP) on the
preservation quality of kidney grafts, we compared mean PPs of 25 and 30 mmHg using a …

A multilevel modeling framework to study hepatic perfusion characteristics in case of liver cirrhosis

G Peeters, C Debbaut… - Journal of …, 2015 - asmedigitalcollection.asme.org
Liver cirrhosis represents the end-stage of different liver disorders, progressively affecting
hepatic architecture, hemodynamics, and function. Morphologically, cirrhosis is …