Over the past 5 years there has been a major transformation in our ability to precisely
manipulate the genomes of animals. Efficiencies of introducing precise genetic alterations in …

Milk and meat from cattle and buffaloes contribute 45% of the global animal protein supply,
followed by chickens (31%), and pigs (20%). In 2016, the global cattle population of 1.0 …

The first genetically modified large animals were developed in 1985 by microinjection to
increase the growth of agricultural livestock such as pigs. Since then, it has been a difficult …

For centuries, animal breeders have intentionally selected the parents of the next generation
based on their concept of the'ideal'animal. The dramatic differences seen in the appearance …

Genome editing is the precise manipulation of genetic material in a living organism by
deleting, replacing, or inserting a DNA sequence to alter the cell's fate or organism's traits. It …

The ability to edit a specific locus in a genome based on targeted DNA nucleases will greatly
facilitate our understanding of the function of a gene in biological research, and have many …

Large animals (non-human primates, livestock and dogs) are playing important roles in
biomedical research, and large livestock animals serve as important sources of meat and …

One of the most powerful strategies to investigate biology we have as scientists, is the ability
to transfer genetic material in a controlled and deliberate manner between organisms. When …

The global demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has minimal impact on the environment will require …

In recent years, significant progress has been achieved in genome editing applications
using new programmable DNA nucleases such as zinc finger nucleases (ZFNs) …