Polymorphism of stress-related genes is a key factor determining difference in the stress
reactivity and resistance among humans. Glucocorticoid receptors are important actors of …

The glucocorticoid and mineralocorticoid receptors are known to play a crucial role in
cellular responses to acute and chronic stress conditions. However, the influence of genetic …

Hyperactivity of the hypothalamus–pituitary–adrenal (HPA) axis has been associated with
the etiology of major depression. One of the factors underlying altered glucocorticoid …

The impacts of glucocorticoids (GCs) are mainly mediated by a nuclear receptor (GR)
existing in almost every tissue. The GR regulates a wide range of physiological functions …

Context: The human glucocorticoid receptor α (GRα) is a nuclear hormone receptor that
regulates multiple physiological and pathophysiological processes. There are large …

Glucocorticoid (GC) resistance can occur in a number of diseases. It can be either
generalized (ie, familial glucocorticoid resistance) or localized (ie, asthma). In many cases, a …

Background: Polymorphism of the gene encoding the glucocorticoid receptor-h-GR/NR3C1
demonstrates close genetic and biochemical correlation with etiopathogenesis of metabolic …

Glucocorticoid receptor (GR) variants have been found to be associated with stress‐related
disorders. Our previous in vivo study revealed that the CC allele of GR B cl I single …

BACKGROUND: Alterations in glucocorticoid (GC) signaling have been associated with a
number of psychiatric disorders. Genetic variation of the glucocorticoid receptor (GR) might …

Following exposure to stress, cortisol is secreted from the adrenal cortex under the control of
the hypothalamic-pituitary-adrenal axis (HPA-axis). Central in the regulation of the HPA-axis …