Objective To detect polymorphisms of glucocorticoid receptor gene (NR3C1) in Chinese
population with the technique of denaturing high-performance liquid chromatography …

Since glucocorticoid exerts its biological effects by binding to its receptor, the expression
efficiency of the glucocorticoid receptor (GR) gene could influence glucocorticoid sensitivity …

The human glucocorticoid receptor isoforms GRα and GRβ are generated by alternative
splicing. Upon hormone binding, GRα regulates positively or negatively transcription. In …

Abstract N363S and ER22/23EK polymorphisms observed within glucocorticoid receptor
gene (NR3C1) may play an important role in the development of bronchial asthma. NR3C1 …

Glucocorticoid receptor (GR) is transcribed in a tissue-and cell-specific manner with multiple
exon 1 mRNA variants driven by selective promoters. We recently cloned and characterized …

The human genome contains numerous single nucleotide variations, and the human
glucocorticoid receptor (GR) gene harbors∼ 450 of these genetic changes. Among them …

Abstract Context: Glucocorticoids (GCs) are extensively used in the treatment of
inflammatory and autoimmune diseases. Their beneficial effects are thought to be mediated …

Background The expression of glucocorticoid-receptor (GR) seems to be a key mechanism
in the regulation of glucocorticoid (GC) sensitivity and is potentially involved in cases of GC …

Exposure to childhood trauma (CT) has been linked to sustained dysregulations of major
stress response systems, including findings of both exaggerated and attenuated …

Although HPA–axis reactivity has repeatedly been related to cognitive functioning, ambiguity
remains regarding the direction of the effect, ie. whether it benefits or impairs functioning …