Both the incidence of, and the mortality due to, prostate cancer in the USA are higher in
African-American men than in Caucasian men. This is particularly true in men less than 60 …

High-grade prostatic intraepithelial neoplasia (PIN) is the earliest accepted stage in
carcinogenesis, possessing most of the phenotypic and biochemical changes in cancer …

About 200000 American men are diagnosed with prostate cancer each year, and millions
more develop undiagnosed preclinical microscopic cancer. About 80% of men have …

High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely pre-
invasive stage of adenocarcinoma, a decade after its first formal description. PIN has a high …

High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely
preinvasive stage of adenocarcinoma, almost two decades after its first formal description …

High-grade prostatic intraepithelial neoplasia (PIN) has been accepted as the main
precursor lesion to invasive adenocarcinoma of the prostate, and this is likely to be the case …

African American men (AAM) demonstrate increased prostate cancer incidence and
mortality rates. We investigated known prostate cancer risk factors in AAM. Prostate specific …

The search for the precursor of prostatic adenocarcinoma has focused in recent years on the
spectrum of histopathologic changes referred to as high grade prostatic intraepithelial …

Aims: To study the prevalence, extent and evolution of high-grade prostatic intraepithelial
neoplasia (HGPIN) in African-American and Caucasian men of a wide age range in order to …

The marked discrepancy between the prevalence of preclinical prostate cancer and the
incidence of clinically manifest disease indicates a long latency phase and significant …