Systematic screening for congenital hypothyroidism in the newborn was introduced some 15
years ago. The main objective was the prevention of mental retardation due to thyroid …

Systematic screening for congenital hypothyroidism in the newborn represents an important
factor in the prevention of mental retardation (See reviews by Dussault et al., 1975; Fisher …

Congenital hypothyroidism is almost the ideal model suited for a mass screening program. If
untreated, the disease leads to irrecuperable mental and physical retardation (Raiti and …

The author reviews the background information and technical developments leading to
newborn screening for congenital hypothyroidism as well as the effectiveness and problems …

In 1977 one of us (DBG) was co-author of an annotation in the Archives on early detection of
congenital hypothyroidism. 1 At that time it was already clear that screening of the newborn …

Recent advances in science and technology have led to the capability of early screening of
newborn infants for congenital hypothyroidism. Preliminary screening programs in North …

The fetal hypothalamic-pituitary-thyroid axis begins to function by midgestation and is
mature in the term infant at delivery. If fetal hypothyroidism develops, untoward effects may …

• High-sensitivity neonatal hypothyroid screening tests are used throughout the country.
Because of low specificity, primary care physicians are faced with an abundance of false …

Background Thyroid hormone deficiency has been recognized as a significant cause of
growth and developmental retardation for almost two centuries (Fisher 1986; Horst and Von …

The horror of cretinism and the joy of its treatment can never havebeen expressed more
vividly than by William Osler, writing in 1897 soon after the effect of thyroid replacement was …