Challenges in drug delivery to the brain: nature is against us

S Krol - Journal of Controlled Release, 2012 - Elsevier
Nanomedicine is a fast evolving field involving nanoparticles or nanostructures for medical
applications. Especially in the underdeveloped field of drug delivery to the brain, there are …

Nanoparticle enabled drug delivery across the blood brain barrier: in vivo and in vitro models, opportunities and challenges

M Gidwani, AV Singh - Current pharmaceutical biotechnology, 2013 - ingentaconnect.com
The blood brain barrier (BBB) maintains homeostasis by regulating the transport of
chemicals at the brain interface. However, it is also one of the largest obstacles for drug …

Precision drug delivery to the central nervous system using engineered nanoparticles

J Gao, Z Xia, S Gunasekar, C Jiang, JM Karp… - Nature Reviews …, 2024 - nature.com
Abstract Development of novel therapies for central nervous system (CNS) disorders has
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …

Nano biomaterials based strategies for enhanced brain targeting in the treatment of neurodegenerative diseases: an up-to-date perspective

DE Nayab, F Din, H Ali, WA Kausar, S Urooj… - Journal of …, 2023 - Springer
Neurons and their connecting axons gradually degenerate in neurodegenerative diseases
(NDs), leading to dysfunctionality of the neuronal cells and eventually their death. Drug …

Therapeutic nanoplatforms and delivery strategies for neurological disorders

YJ Kang, EG Cutler, H Cho - Nano Convergence, 2018 - Springer
The major neurological disorders found in a central nervous system (CNS), such as brain
tumors, Alzheimer's diseases, Parkinson's diseases, and Huntington's disease, have led to …

Nanoparticle-based drug delivery systems: an inspiring therapeutic strategy for neurodegenerative diseases

L Duan, X Li, R Ji, Z Hao, M Kong, X Wen, F Guan… - Polymers, 2023 - mdpi.com
Neurodegenerative diseases are common, incurable neurological disorders with high
prevalence, and lead to memory, movement, language, and intelligence impairments …

The delivery challenge in neurodegenerative disorders: the nanoparticles role in Alzheimer's disease therapeutics and diagnostics

C De la Torre, V Ceña - Pharmaceutics, 2018 - mdpi.com
Alzheimer's disease (AD) is one of the main causes of disability and dependency among
elderly people. AD is a neurodegenerative disorder characterized by a progressive and …

Treating Alzheimer's disease using nanoparticle-mediated drug delivery strategies/systems

AK Roghani, RI Garcia, A Roghani, A Reddy… - Ageing Research …, 2024 - Elsevier
The administration of promising medications for the treatment of neurodegenerative
disorders (NDDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's …

Nanocarriers for effective nutraceutical delivery to the brain

R Meenambal, MMS Bharath - Neurochemistry International, 2020 - Elsevier
Neurodegenerative disorders are common among aging populations around the globe.
Most are characterized by loss of neurons, protein aggregates, oxidative stress …

Nano-interventions for neurodegenerative disorders

C Fernandes, U Soni, V Patravale - Pharmacological research, 2010 - Elsevier
With an increase in lifespan and changing population demographics, the incidence of
central nervous system (CNS) diseases is expected to increase significantly in the 21st …