Challenges in drug delivery to the brain: nature is against us
S Krol - Journal of Controlled Release, 2012 - Elsevier
Nanomedicine is a fast evolving field involving nanoparticles or nanostructures for medical
applications. Especially in the underdeveloped field of drug delivery to the brain, there are …
applications. Especially in the underdeveloped field of drug delivery to the brain, there are …
Nanoparticle enabled drug delivery across the blood brain barrier: in vivo and in vitro models, opportunities and challenges
M Gidwani, AV Singh - Current pharmaceutical biotechnology, 2013 - ingentaconnect.com
The blood brain barrier (BBB) maintains homeostasis by regulating the transport of
chemicals at the brain interface. However, it is also one of the largest obstacles for drug …
chemicals at the brain interface. However, it is also one of the largest obstacles for drug …
Precision drug delivery to the central nervous system using engineered nanoparticles
Abstract Development of novel therapies for central nervous system (CNS) disorders has
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …
Nano biomaterials based strategies for enhanced brain targeting in the treatment of neurodegenerative diseases: an up-to-date perspective
Neurons and their connecting axons gradually degenerate in neurodegenerative diseases
(NDs), leading to dysfunctionality of the neuronal cells and eventually their death. Drug …
(NDs), leading to dysfunctionality of the neuronal cells and eventually their death. Drug …
Therapeutic nanoplatforms and delivery strategies for neurological disorders
The major neurological disorders found in a central nervous system (CNS), such as brain
tumors, Alzheimer's diseases, Parkinson's diseases, and Huntington's disease, have led to …
tumors, Alzheimer's diseases, Parkinson's diseases, and Huntington's disease, have led to …
Nanoparticle-based drug delivery systems: an inspiring therapeutic strategy for neurodegenerative diseases
L Duan, X Li, R Ji, Z Hao, M Kong, X Wen, F Guan… - Polymers, 2023 - mdpi.com
Neurodegenerative diseases are common, incurable neurological disorders with high
prevalence, and lead to memory, movement, language, and intelligence impairments …
prevalence, and lead to memory, movement, language, and intelligence impairments …
The delivery challenge in neurodegenerative disorders: the nanoparticles role in Alzheimer's disease therapeutics and diagnostics
C De la Torre, V Ceña - Pharmaceutics, 2018 - mdpi.com
Alzheimer's disease (AD) is one of the main causes of disability and dependency among
elderly people. AD is a neurodegenerative disorder characterized by a progressive and …
elderly people. AD is a neurodegenerative disorder characterized by a progressive and …
Treating Alzheimer's disease using nanoparticle-mediated drug delivery strategies/systems
AK Roghani, RI Garcia, A Roghani, A Reddy… - Ageing Research …, 2024 - Elsevier
The administration of promising medications for the treatment of neurodegenerative
disorders (NDDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's …
disorders (NDDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's …
Nanocarriers for effective nutraceutical delivery to the brain
R Meenambal, MMS Bharath - Neurochemistry International, 2020 - Elsevier
Neurodegenerative disorders are common among aging populations around the globe.
Most are characterized by loss of neurons, protein aggregates, oxidative stress …
Most are characterized by loss of neurons, protein aggregates, oxidative stress …
Nano-interventions for neurodegenerative disorders
C Fernandes, U Soni, V Patravale - Pharmacological research, 2010 - Elsevier
With an increase in lifespan and changing population demographics, the incidence of
central nervous system (CNS) diseases is expected to increase significantly in the 21st …
central nervous system (CNS) diseases is expected to increase significantly in the 21st …