The impact of common and rare EGFR mutations in response to EGFR tyrosine kinase inhibitors and platinum-based chemotherapy in patients with non-small cell …

O Arrieta, AF Cardona, L Corrales, AD Campos-Parra… - Lung cancer, 2015 - Elsevier
Objectives In non-small cell lung cancer (NSCLC), the association between common EGFR
mutations (Del EX19/L858R) with EGFR tyrosine kinase inhibitors (EGFR-TKIs) has been …

[HTML][HTML] Efficacy analysis of tyrosine kinase inhibitors on rare non-small cell lung cancer patients harboring complex EGFR mutations

L Peng, ZG Song, SC Jiao - Scientific reports, 2014 - nature.com
The efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) in
patients with non-small cell lung cancer (NSCLC) is related to EGFR mutations. Although the …

[HTML][HTML] Association between EGFR exon 19 or exon 21 mutations and survival rates after first‑line EGFR‑TKI treatment in patients with non‑small cell lung cancer

H Jiang, M Zhu, Y Li, Q Li - Molecular and clinical …, 2019 - spandidos-publications.com
Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‑TKI) is the first‑line
treatment for patients with advanced non‑small‑cell lung cancer (NSCLC) who have an …

Comparison of uncommon EGFR exon 21 L858R compound mutations with single mutation

L Peng, Z Song, S Jiao - OncoTargets and therapy, 2015 - Taylor & Francis
Non-small-cell lung cancer with epidermal growth factor receptor (EGFR) mutation is
sensitive to EGFR tyrosine kinase inhibitors (TKIs). But little is known about the response to …

[HTML][HTML] Clinical and molecular characteristics of non-small-cell lung cancer (NSCLC) harboring EGFR mutation: results of the nationwide French Cooperative …

C Leduc, JP Merlio, B Besse, H Blons, D Debieuvre… - Annals of …, 2017 - Elsevier
Background EGFR mutations cause inconsistent response to EGFR tyrosine-kinase
inhibitors (TKI). To better understand these features, we reviewed all cases of EGFR …

[HTML][HTML] Uncommon EGFR mutations in a cohort of Chinese NSCLC patients and outcomes of first-line EGFR-TKIs and platinum-based chemotherapy

J Shi, H Yang, T Jiang, X Li, C Zhao… - Chinese Journal of …, 2017 - ncbi.nlm.nih.gov
Objective Data on the clinical activity of epidermal growth factor receptor (EGFR) tyrosine
kinase inhibitors (TKIs) in patients with non-small-cell lung cancer (NSCLC) and uncommon …

[HTML][HTML] Uncommon EGFR mutations in non-small-cell lung cancer: A systematic literature review of prevalence and clinical outcomes

T John, A Taylor, H Wang, C Eichinger, C Freeman… - Cancer …, 2022 - Elsevier
Mutations in exons 18–21 of the epidermal growth factor receptor gene (EGFR) can confer
sensitivity to EGFR-tyrosine kinase inhibitors (EGFR-TKIs) in patients with non-small-cell …

Activity of EGFR TKIs in Caucasian patients with NSCLC harboring potentially sensitive uncommon EGFR mutations

A Passaro, A Prelaj, L Bonanno, M Tiseo, A Tuzi… - Clinical lung cancer, 2019 - Elsevier
Background Molecular characterization of non–small-cell lung cancer (NSCLC), defined
predictive and druggable mutations that greatly modified patient prognoses. The most …

EGFR tyrosine kinase inhibitor (TKI) in patients with advanced non-small cell lung cancer (NSCLC) harboring uncommon EGFR mutations: A real-world study in China

J Xu, B Jin, T Chu, X Dong, H Yang, Y Zhang, D Wu… - Lung cancer, 2016 - Elsevier
Introduction There are a number of uncommon EGFR mutations whose associations with
TKIs are not well clarified. Here, we summarize the clinical data of patients with multiple …

Tyrosine Kinase Inhibitor Activity in Patients with NSCLC Harboring Uncommon EGFR Mutations: A Retrospective International Cohort Study (UpSwinG)

S Popat, TC Hsia, JY Hung, HA Jung, JY Shih… - The …, 2022 - academic.oup.com
Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are
standard of care for patients with EGFR mutation-positive non–small-cell lung cancer …