Background Spinocerebellar ataxia (SCA) subtypes are often caused by expansions in non-
coding regions of genes like SCA8, SCA10, SCA12 and SCA36. Other ataxias are known to …

In order to clarify the clinical and genetic features of SCA6, we retrospectively analyzed 140
patients. We observed an inverse correlation between the age of onset and the length of the …

Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disorder
caused by the expansion of an unstable (CAG) n repeat on chromosome 6p. We …

The autosomal dominant ataxias are a heterogenous group of disorders. Almost 30 different
genetic loci have been identified. Spinocerebellar ataxia type 2 (SCA2) is one of many …

Background Spinocerebellar ataxias are dominantly inherited neurodegenerative diseases.
As potential treatments for these diseases are being developed, precise knowledge of their …

The functional Scale for the Assessment and Rating of Ataxia (f-SARA) assesses Gait,
Stance, Sitting, and Speech. It was developed as a potentially clinically meaningful measure …

This study aimed to determine the prevalence and type of extrapyramidal signs (EPS) in
spinocerebellar ataxia (SCA) type 1, 2 and 3. Eighty-five patients with genetically confirmed …

Nonmotor symptoms (NMS) have been described in several neurodegenerative diseases
but have not been systematically evaluated in spinocerebellar ataxia type 10 (SCA10). The …

Spinocerebellar ataxias (SCAs) are progressive neurodegenerative disorders, but there is
no metric that predicts disease severity over time. We hypothesized that by developing a …

OBJECTIVES: Cognitive disorders and dementia occur in 19 to 42% of patients with
spinocerebellar ataxia type 2 (SCA2). Neuropsychological tests can reveal executive …