We understand much about the agents, receptors, and signalling pathways that lead to
immunity to pathogens. Less is known about how the process is initiated in apparently sterile …

Dendritic cells (DCs) are potent antigen-presenting cells critical in regulating the adaptive
immune response. The role of DCs is dichotomous; they may both present antigens and the …

Two events characterize tissue injury and sterile inflammation:(1) generation/release of
autoantigens, and (2) generation of homeostatic inflammatory signals. Homeostatic signals …

Dendritic cells (DCs) initiate and control immune responses, participate in the maintenance
of immunological tolerance and are pivotal players in the pathogenesis of autoimmunity. In …

Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …

Dying cells have an important role in the initiation of CD8+ T cell-mediated immunity. The
cross-presentation of antigens derived from dying cells enables dendritic cells to present …

The immunogenicity of malignant cells has recently been acknowledged as a critical
determinant of efficacy in cancer therapy. Thus, besides developing direct …

Sterile inflammation can be initiated by innate immune recognition of markers of tissue injury
termed damage-associated molecular patterns (DAMPs). DAMP recognition by dendritic …

Associated with the development of hospital-acquired infections, major traumatic injury
results in an immediate and persistent state of systemic immunosuppression, yet the …

The immune system plays an essential role in protecting the host against infections and to
accomplish this task has evolved mechanisms to recognize microbes and destroy them. In …