Effector target-guided engineering of an integrated domain expands the disease resistance profile of a rice NLR immune receptor
JHR Maidment, M Shimizu, AR Bentham, S Vera… - Elife, 2023 - elifesciences.org
A subset of plant intracellular NLR immune receptors detect effector proteins, secreted by
phytopathogens to promote infection, through unconventional integrated domains which …
phytopathogens to promote infection, through unconventional integrated domains which …
[HTML][HTML] Cross-reactivity of a rice NLR immune receptor to distinct effectors from the rice blast pathogen Magnaporthe oryzae provides partial disease resistance
FA Varden, H Saitoh, K Yoshino… - Journal of Biological …, 2019 - ASBMB
Unconventional integrated domains in plant intracellular immune receptors of the nucleotide-
binding leucine-rich repeat (NLRs) type can directly bind translocated effector proteins from …
binding leucine-rich repeat (NLRs) type can directly bind translocated effector proteins from …
[HTML][HTML] Protein engineering expands the effector recognition profile of a rice NLR immune receptor
JC De la Concepcion, M Franceschetti, D MacLean… - elife, 2019 - elifesciences.org
Plant nucleotide binding, leucine-rich repeat (NLR) receptors detect pathogen effectors and
initiate an immune response. Since their discovery, NLRs have been the focus of protein …
initiate an immune response. Since their discovery, NLRs have been the focus of protein …
Allelic compatibility in plant immune receptors facilitates engineering of new effector recognition specificities
AR Bentham, JC De la Concepcion… - The Plant …, 2023 - academic.oup.com
Engineering the plant immune system offers genetic solutions to mitigate crop diseases
caused by diverse agriculturally significant pathogens and pests. Modification of intracellular …
caused by diverse agriculturally significant pathogens and pests. Modification of intracellular …
[HTML][HTML] Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor
A Maqbool, H Saitoh, M Franceschetti, CEM Stevenson… - elife, 2015 - elifesciences.org
Plants have evolved intracellular immune receptors to detect pathogen proteins known as
effectors. How these immune receptors detect effectors remains poorly understood. Here we …
effectors. How these immune receptors detect effectors remains poorly understood. Here we …
[HTML][HTML] Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain
A Białas, T Langner, A Harant, MP Contreras… - Elife, 2021 - elifesciences.org
A subset of plant NLR immune receptors carry unconventional integrated domains in
addition to their canonical domain architecture. One example is rice Pik-1 that comprises an …
addition to their canonical domain architecture. One example is rice Pik-1 that comprises an …
Bioengineering a plant NLR immune receptor with a robust binding interface toward a conserved fungal pathogen effector
R Zdrzałek, Y Xi, T Langner, AR Bentham… - Proceedings of the …, 2024 - pnas.org
Bioengineering of plant immune receptors has emerged as a key strategy for generating
novel disease resistance traits to counteract the expanding threat of plant pathogens to …
novel disease resistance traits to counteract the expanding threat of plant pathogens to …
[HTML][HTML] New recognition specificity in a plant immune receptor by molecular engineering of its integrated domain
S Cesari, Y Xi, N Declerck, V Chalvon… - Nature …, 2022 - nature.com
Plant nucleotide-binding and leucine-rich repeat domain proteins (NLRs) are immune
sensors that recognize pathogen effectors. Here, we show that molecular engineering of the …
sensors that recognize pathogen effectors. Here, we show that molecular engineering of the …
Polymorphic residues in rice NLRs expand binding and response to effectors of the blast pathogen
JC De la Concepcion, M Franceschetti, A Maqbool… - Nature plants, 2018 - nature.com
Accelerated adaptive evolution is a hallmark of plant–pathogen interactions. Plant
intracellular immune receptors (NLRs) often occur as allelic series with differential pathogen …
intracellular immune receptors (NLRs) often occur as allelic series with differential pathogen …
[HTML][HTML] The allelic rice immune receptor Pikh confers extended resistance to strains of the blast fungus through a single polymorphism in the effector binding interface
Arms race co-evolution drives rapid adaptive changes in pathogens and in the immune
systems of their hosts. Plant intracellular NLR immune receptors detect effectors delivered …
systems of their hosts. Plant intracellular NLR immune receptors detect effectors delivered …
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