We have previously shown that IsdB, a conserved protein expressed by Staphylococcus
aureus, induces a robust antibody response which correlates with protection in a murine …

We previously reported the development of a human monoclonal antibody (CS-D7, IgG1)
with specificity and affinity for the iron regulated surface determinant B (IsdB) of …

Staphylococcus aureus is frequently detected in patients with sepsis and thus represents a
major health burden worldwide. CD4+ T helper cells are involved in the immune response to …

A fully human monoclonal antibody (CS-D7, IgG 1) specific for the iron regulated surface
determinant B (IsdB) of Staphylococcus aureus was isolated from the Cambridge Antibody …

Staphylococcus aureus is prevalent in surgical site infections (SSI) and leads to death in
approximately 1% of patients. Phase IIB/III clinical trial results have demonstrated that …

Staphylococcus aureus is the most common cause of skin and soft tissue infections, and
rapidly emerging antibiotic-resistant strains are creating a serious public health concern. If …

The human commensal Staphylococcus aureus (SA) is a leading cause of skin/soft tissue
and surgical-site infections, and bacteremia. Functional antibodies and T-cell-mediated …

The development of vaccines against Staphylococcus aureus has consistently failed in
clinical trials, likely due to inefficient induction of cellular immunity. T cell–derived IL-17 is …

The nutrient metal iron plays a key role in the survival of microorganisms. The iron-regulated
surface determinant (Isd) system scavenges heme-iron from the human host, enabling …

The opportunistic pathogen Staphylococcus aureus (S. aureus) is a major cause of
nosocomial-and community-acquired infections. In addition, many antibiotic-resistant strains …