[HTML][HTML] Exploring alternative antibody scaffolds: Antibody fragments and antibody mimics for targeted drug delivery
DA Richards - Drug Discovery Today: Technologies, 2018 - Elsevier
The field of targeted therapeutics has benefitted immeasurably from the development of high-
affinity antibodies. These important ligands have facilitated the development of effective …
affinity antibodies. These important ligands have facilitated the development of effective …
The state-of-play and future of antibody therapeutics
Z Elgundi, M Reslan, E Cruz, V Sifniotis… - Advanced drug delivery …, 2017 - Elsevier
It has been over four decades since the development of monoclonal antibodies (mAbs)
using a hybridoma cell line was first reported. Since then more than thirty therapeutic …
using a hybridoma cell line was first reported. Since then more than thirty therapeutic …
Antibodies and associates: Partners in targeted drug delivery
PJ Kennedy, C Oliveira, PL Granja… - Pharmacology & …, 2017 - Elsevier
Monoclonal antibodies (mAbs) are well established in the clinic due to their specificity and
affinity to a diverse array of biochemical targets. More recently, mAbs are being exploited as …
affinity to a diverse array of biochemical targets. More recently, mAbs are being exploited as …
Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry
P Akkapeddi, SA Azizi, AM Freedy, PMSD Cal… - Chemical …, 2016 - pubs.rsc.org
Systemic chemotherapy, the current standard of care for the treatment of cancer, is rarely
curative and is often accompanied by debilitating side effects. Targeted drug delivery stands …
curative and is often accompanied by debilitating side effects. Targeted drug delivery stands …
Site-specific antibody–drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development
P Agarwal, CR Bertozzi - Bioconjugate chemistry, 2015 - ACS Publications
Antibody–drug conjugates (ADCs) combine the specificity of antibodies with the potency of
small molecules to create targeted drugs. Despite the simplicity of this concept, generation of …
small molecules to create targeted drugs. Despite the simplicity of this concept, generation of …
Next generation antibody drugs: pursuit of the'high-hanging fruit'
PJ Carter, GA Lazar - Nature Reviews Drug Discovery, 2018 - nature.com
Antibodies are the most rapidly growing drug class and have a major impact on human
health, particularly in oncology, autoimmunity and chronic inflammatory diseases. Many of …
health, particularly in oncology, autoimmunity and chronic inflammatory diseases. Many of …
Site-selective modification strategies in antibody–drug conjugates
SJ Walsh, JD Bargh, FM Dannheim… - Chemical Society …, 2021 - pubs.rsc.org
Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …
Current status: site-specific antibody drug conjugates
D Schumacher, CPR Hackenberger… - Journal of clinical …, 2016 - Springer
Antibody drug conjugates (ADCs), a promising class of cancer biopharmaceuticals, combine
the specificity of therapeutic antibodies with the pharmacological potency of chemical …
the specificity of therapeutic antibodies with the pharmacological potency of chemical …
Novel formats of antibody conjugates: recent advances in payload diversity, conjugation, and linker chemistry
T Fujii, Y Matsuda - Expert Opinion on Biological Therapy, 2023 - Taylor & Francis
Introduction In the field of bioconjugates, the focus on antibody–drug conjugates (ADCs)
with novel payloads beyond the traditional categories of potent cytotoxic agents is …
with novel payloads beyond the traditional categories of potent cytotoxic agents is …
Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)
RM Hoffmann, BGT Coumbe, DH Josephs… - …, 2018 - Taylor & Francis
Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy,
combining the antibody's exquisite specificity for the target antigen-expressing cancer cell …
combining the antibody's exquisite specificity for the target antigen-expressing cancer cell …