Cathepsin C (CatC) is a tetrameric cysteine dipeptidyl aminopeptidase that plays a key role
in activation of pro-inflammatory serine protease zymogens by removal of a N-terminal pro …

Inhibition of cathepsin C, a dipeptidyl peptidase that activates many serine proteases,
represents an attractive therapeutic strategy for inflammatory diseases with a high neutrophil …

Cathepsin C is a cysteine protease required for the activation of several pro-inflammatory
serine proteases and, as such, is of interest as a therapeutic target. In cathepsin C-deficient …

Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl
aminopeptidase. The best characterized physiological function of CatC is the activation of …

The lysosomal cysteine protease cathepsin C (Cat C), also known as dipeptidyl peptidase I,
activates a number of granule-associated serine proteases with pro-inflammatory and …

The cysteine protease cathepsin C (CatC) activates granule-associated proinflammatory
serine proteases in hematopoietic precursor cells. Its early inhibition in the bone marrow is …

Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …

Abstract Cathepsin C (CatC, syn. Dipeptidyl peptidase I) is a lysosomal cysteine proteinase
expressed in several tissues including inflammatory cells. This enzyme is important for …

Cathepsin C (CatC) is a dipeptidyl-exopeptidase which activates neutrophil serine protease
precursors (elastase, proteinase 3, cathepsin G and NSP4) by removing their N-terminal …

Human secretory leukocyte protease inhibitor (SLPI) is a predominant physiologic inhibitor
of elastase and cathepsin G, proinflammatory serine proteases released by activated …