Due to continuous changes to its antigenic regions, influenza viruses can evade immune
detection and cause a significant amount of morbidity and mortality around the world …

Most neutralizing antibodies elicited during influenza virus infection or vaccination target
immunodominant, variable epitopes on the globular head region of hemagglutinin (HA) …

The conserved influenza virus hemagglutinin (HA) stem domain elicits cross-reactive
antibodies, but epitopes in the globular head typically elicit strain-specific responses …

ABSTRACT A human monoclonal heterosubtypic antibody, MAb 3.1, with its heavy chain
encoded by VH3-30, was isolated using phage display with immobilized hemagglutinin (HA) …

Seasonal epidemics caused by antigenic variations in influenza A virus remain a public
health concern and an economic burden. The isolation and characterization of broadly …

Effective annual influenza vaccination requires frequent changes in vaccine composition
due to both antigenic shift for different subtype hemagglutinins (HAs) and antigenic drift in a …

Influenza A virus infection is a persistent threat to public health worldwide due to its ability to
evade immune surveillance through rapid genetic drift and shift. Current vaccines against …

Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that
recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts …

Background Human antibodies that interfere with the biological activity of haemagglutinins
(HAs) of influenza viruses have high potential as an antiviral agent. Methods Human single …

The spread of the recently emerged, highly pathogenic H5N1 avian influenza virus has
raised concern. Preclinical studies suggest that passive immunotherapy could be a new …