Antibodies to aquaporin-4 (also known as AQP4-Ab or NMO-IgG) are sensitive and highly
specific serum markers of autoimmune neuromyelitis optica (NMO). Second-generation …

Abstract Background In 70-80% of cases, neuromyelitis optica (NMO) is associated with
highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG) …

Neuromyelitis optica (NMO) is a severe inflammatory CNS disorder of putative autoimmune
aetiology, which predominantly affects the spinal cord and optic nerves. Recently, a highly …

Neuromyelitis optica (NMO) is a severe, debilitating human disease that predominantly
features immunopathology in the optic nerves and the spinal cord. An IgG1 autoantibody …

Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are
unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water …

Background Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous
system (CNS) of putative autoimmune aetiology. Early discrimination between multiple …

Neuromyelitis optica (NMO) is a rare CNS inflammatory disorder that predominantly affects
the optic nerves and spinal cord. Recent serological findings strongly suggest that NMO is a …

Abstract Aquaporin‐4 (AQP 4) is a water channel protein that is most highly, but not
exclusively, expressed in the central nervous system. In 2005 AQP 4 was shown to be the …

Objective: To optimize aquaporin-4 (AQP4) antibody (Ab) detection and to assess the
influence of the increased sensitivity of the assay on the demographic and disease-related …

Antibodies to aquaporin‐4 (called NMO‐IgG or AQP4‐Ab) constitute a sensitive and highly
specific serum marker of neuromyelitis optica (NMO) that can facilitate the differential …