Low-dose xenogeneic mesenchymal stem cells target canine osteoarthritis through systemic immunomodulation and homing

C Beerts, SY Broeckx, E Depuydt, L Tack… - Arthritis Research & …, 2023 - Springer
Background As current therapies for canine osteoarthritis (OA) provide mainly symptomatic
improvement and fail to address the complex pathology of the disease, mesenchymal stem …

Intra-articular xenogeneic mesenchymal stem cell-based therapy increases CD4+ CD25+ cells in synovial fluid

K Lamers, M Baquero, N Karrow, M Hurtig - Veterinary Immunology and …, 2020 - Elsevier
Osteoarthritis (OA) is a chronic joint disease afflicting a substantial portion of the world's
population with no currently available cure. Mesenchymal stem cell (MSC)-based therapies …

Mesenchymal stem cell therapy in canine osteoarthritis research:“experientia docet”(experience will teach us)

C Brondeel, G Pauwelyn, E De Bakker… - Frontiers in Veterinary …, 2021 - frontiersin.org
Osteoarthritis (OA) is currently an incurable and progressive condition in dogs causing
chronic joint pain and possibly increasing disability. Due to the poor healing capacity of …

A feasibility study on the use of equine chondrogenic induced mesenchymal stem cells as a treatment for natural occurring osteoarthritis in dogs

R Daems, L Van Hecke, I Schwarzkopf… - Stem Cells …, 2019 - Wiley Online Library
Conventional treatments of osteoarthritis (OA) reduce pain and the inflammatory response
but do not repair the damaged cartilage. Xenogeneic peripheral blood‐derived equine …

Intravenous injection of equine mesenchymal stem cells in dogs with articular pain and lameness: A feasibility study

C Brondeel, F Weekers, L van Hecke… - Stem Cells and …, 2023 - liebertpub.com
Osteoarthritis is a frequently occurring joint disorder in veterinary practice. Current
treatments are focused on pain and inflammation; however, these are not able to reverse the …

Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis

O Kehoe, A Cartwright, A Askari, AJ El Haj… - Journal of translational …, 2014 - Springer
Background Rheumatoid arthritis (RA) is a debilitating and painful disease leading to
increased morbidity and mortality and novel therapeutic approaches are needed. The …

[HTML][HTML] Intra-articular injection of human synovium-derived mesenchymal stem cells in beagles with surgery-induced osteoarthritis

YS Kim, YI Kim, YG Koh - The Knee, 2021 - Elsevier
Background Recently, cell-based tissue engineering approaches using mesenchymal stem
cells (MSCs) have been used to treat osteoarthritis (OA). However, the efficacy of human …

Assessment of effectiveness and safety of repeat administration of proinflammatory primed allogeneic mesenchymal stem cells in an equine model of chemically …

L Barrachina, AR Remacha, A Romero, A Vitoria… - BMC veterinary …, 2018 - Springer
Background This study aimed at assessing the effectiveness and safety of repeated
administrations of allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs) …

Homing of radiolabelled xenogeneic equine peripheral blood-derived MSCs towards a joint lesion in a dog

C Beerts, G Pauwelyn, E Depuydt, Y Xu… - Frontiers in Veterinary …, 2022 - frontiersin.org
Osteoarthritis (OA) is a highly prevalent condition in dogs, causing a substantial reduction in
quality of life and welfare of the animals. Current disease management focusses on pain …

Cell-free therapy for canine osteoarthritis: current evidence and prospects

K Sharun, S Muthu, PD Mankuzhy, AM Pawde… - Veterinary …, 2022 - Taylor & Francis
Osteoarthritis is a progressive degenerative disease affecting joints. It is associated with
structural and functional changes that cause lameness and pain in dogs. Mesenchymal stem …