Iron enhances endothelial cell activation in response to Cytomegalovirus or Chlamydia pneumoniae infection

AER Kartikasari, NA Georgiou… - European journal of …, 2006 - Wiley Online Library
Background Chronic inflammation has been implemented in the pathogenesis of
inflammatory diseases like atherosclerosis. Several pathogens like Chlamydia pneumoniae …

Iron chelation and hydroxyl radical scavenging reduce the inflammatory response of endothelial cells after infection with Chlamydia pneumoniae or influenza A

FLJ Visseren, MSA Verkerk… - European journal of …, 2002 - Wiley Online Library
Background Chronic low‐grade inflammation is associated with increased risk of vascular
diseases. The source of inflammation is unknown but may well be chronic and/or repetitive …

Intracellular labile iron promotes firm adhesion of human monocytes to endothelium under flow and transendothelial migration: iron and monocyte–endothelial cell …

AER Kartikasari, FLJ Visseren, JJM Marx… - Atherosclerosis, 2009 - Elsevier
Monocyte infiltration across the endothelium is part of the innate immune response, however
it may contribute to severity of chronic conditions. We have investigated the effects of iron on …

Intracellular labile iron modulates adhesion of human monocytes to human endothelial cells

AER Kartikasari, NA Georgiou… - … , and vascular biology, 2004 - Am Heart Assoc
Objective—Elevated iron stores and high plasma iron concentration have been linked to an
increased risk of atherosclerosis. Iron may thereby affect the interaction of monocytes to …

[HTML][HTML] Iron Homeostasis in Tissues Is Affected during Persistent Chlamydia pneumoniae Infection in Mice

M Edvinsson, J Tallkvist… - BioMed Research …, 2017 - hindawi.com
Chlamydia pneumoniae (C. pneumoniae) may be a mediator in the pathogenesis of
atherosclerosis. For its growth C. pneumoniae depends on iron (Fe), but how Fe changes in …

[HTML][HTML] The effect of circulating iron on barrier integrity of primary human endothelial cells

MC Madsen, F Podieh, MC Overboom, A Thijs… - Scientific reports, 2023 - nature.com
Iron is hypothesized to be one of the contributors to cardiovascular disease and its levels in
the circulation may correlate with cardiovascular risk. The aim of this study is to investigate …

Role of inflammation and infection in vascular disease

E Corrado, S Novo - Acta Chirurgica Belgica, 2005 - Taylor & Francis
Relationship of infection, inflammation, and atherosclerosis has been a subject of intensive
investigation in recent years. Potential mechanisms whereby chronic infections may play a …

[HTML][HTML] New insights into the role of iron in inflammation and atherosclerosis

A Cornelissen, L Guo, A Sakamoto, R Virmani… - …, 2019 - thelancet.com
Iron is fundamental for life-essential processes. However, it can also cause oxidative
damage, which is thought to trigger numerous pathologies, including cardiovascular …

Serum iron, infection and inflammation; effects on coronary risk

H Kervinen, L Tenkanen, T Palosuo… - Scandinavian …, 2004 - Taylor & Francis
Objectives—To explore the potential pathways of association between serum iron and
coronary heart disease, with major emphasis on factors related to infections and …

Divergent modulation of Chlamydia pneumoniae infection cycle in human monocytic and endothelial cells by iron, tryptophan availability and interferon gamma

R Bellmann-Weiler, V Martinz, K Kurz, S Engl… - Immunobiology, 2010 - Elsevier
Chlamydia pneumoniae is an obligatory intracellular bacterium causing chronic
inflammatory diseases in humans. We studied the role of the nutritive factors, iron and …