Abstract Background Histone deacetylase 4 (HDAC4) is a stress‐responsive factor that
mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles …

Background Denervation triggers numerous molecular responses in skeletal muscle,
including the activation of catabolic pathways and oxidative stress, leading to progressive …

Duchenne muscular dystrophy (DMD) causes progressive skeletal muscle degeneration
and currently there are few therapeutic options. The identification of new drug targets and …

Histone deacetylase 11 (HDAC11) is the latest identified member of the histone deacetylase
family of enzymes. It is highly expressed in brain, heart, testis, kidney, and skeletal muscle …

HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to
denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially …

The absence of dystrophin in Duchenne muscular dystrophy disrupts the dystrophin-
associated glycoprotein complex resulting in skeletal muscle fiber fragility and atrophy …

BACKGROUND: Skeletal muscle atrophy during aging, a process known as sarcopenia, is
associated with muscle weakness, frailty, and the loss of independence in older adults. The …

Histone deacetylases (HDACs) are enzymes that regulate the deacetylation of numerous
histone and non-histone proteins, thereby affecting a wide range of cellular processes …

Skeletal muscle possesses a high ability to regenerate after an insult or in pathological
conditions, relying on satellite cells, the skeletal muscle stem cells. Satellite cell behavior is …

The overlapping histological and biochemical features underlying the beneficial effect of
deacetylase inhibitors and NO donors in dystrophic muscles suggest an unanticipated …